Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 4/20 | 0.74 |
| ▸ | MMP3 | P08254 | 1/20 | 0.72 |
| ▸ | MMP7 | P09237 | 1/20 | 0.72 |
| ▸ | MMP10 | P09238 | 1/20 | 0.72 |
| ▸ | MMP9 | P14780 | 1/20 | 0.72 |
| ▸ | MMP8 | P22894 | 1/20 | 0.72 |
| ▸ | MMP12 | P39900 | 1/20 | 0.72 |
| ▸ | MMP13 | P45452 | 1/20 | 0.72 |
| ▸ | MMP14 | P50281 | 1/20 | 0.72 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7541292 | 1.00 | MMP2 (0.74) | MMP2MMP3MMP7MMP10MMP9 | |
| SCHEMBL5898078 | 1.00 | MMP2 (0.74) | MMP2MMP3MMP7MMP10MMP9 | |
| SCHEMBL7541276 | 1.00 | MMP2 (0.74) | MMP2MMP3MMP7MMP10MMP9 | |
| Trifluoroacetic Acid SCHEMBL5898174 | 0.96 | MMP2 (0.68) | MMP2MMP3MMP7MMP10MMP9 | |
| SCHEMBL5897789 | 0.95 | MMP2 (0.75) | MMP2MMP3MMP7MMP10MMP9 | |
| SCHEMBL5897901 | 0.92 | MMP2 (0.76) | MMP2MMP3MMP7MMP10MMP9 | |
| SCHEMBL5898044 | 0.91 | MMP2 (0.76) | MMP2 | |
| SCHEMBL5898112 | 0.91 | ADAM17 (0.76) | MMP2MMP3MMP7MMP10MMP9 | |
| SCHEMBL5898238 | 0.91 | MMP2 (0.74) | MMP2MMP3MMP7MMP10MMP9 | |
| SCHEMBL5898229 | 0.91 | MMP2 (0.87) | MMP2MMP3MMP7MMP10MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1263755-A2 | CYCLIC BETA-AMINO ACID DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEASES AND TNF-ALPHA | Bristol-Myers Squibb Pharma Company (US) | 2002-12-11 | — | — | EP | disclosed |
| WO-2001070673-A2 | CYCLIC β-AMINO ACID DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEASES AND TNF-$g(a) | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2001-09-27 | — | — | WO | disclosed |