Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.36 |
| ▸ | CCR4 | P51679 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.33 |
| ▸ | EDNRA | P25101 | 1/20 | 0.33 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | KMO | O15229 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7541379 | 0.84 | NPSR1 (0.47) | POLBKDM4EL3MBTL1CCR4ALDH1A1 | |
| SCHEMBL3170311 | 0.84 | POLB (0.42) | POLBCCR4SIRT6EDNRA | |
| SCHEMBL7547389 | 0.82 | KDM4E (0.41) | TDP1KDM4EKMT2AALDH1A1HPGD | |
| SCHEMBL10328705 | 0.81 | POLB (0.51) | POLBTDP1KDM4EMEN1KMT2A | |
| SCHEMBL14780231 | 0.80 | MEN1 (0.44) | POLBTDP1CCR4MEN1KMT2A | |
| SCHEMBL7543209 | 0.80 | ALDH1A1 (0.43) | L3MBTL1ALDH1A1HPGDHSD17B10MAPT | |
| SCHEMBL27872630 | 0.78 | PDE10A (0.41) | POLBTDP1KDM4EKMT2A | |
| SCHEMBL29432473 | 0.78 | ALDH1A1 (0.41) | TDP1KDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL6100470 | 0.78 | ALDH1A1 (0.41) | TDP1KDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL5767151 | 0.76 | NPSR1 (0.47) | KDM4EL3MBTL1MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0889038-B1 | Process for the preparation of alkoxy-or aryloxypyrazine derivatives | LONZA AG (CH) | 2002-05-29 | — | — | EP | claimed |