Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | CCR4 | P51679 | 2/20 | 0.37 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.36 |
| ▸ | ATM | Q13315 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | EDNRA | P25101 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | GMNN | O75496 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1475724 | 0.86 | NPSR1 (0.47) | NPSR1GAAKDM4EALDH1A1CCR4 | |
| SCHEMBL7543209 | 0.85 | ALDH1A1 (0.43) | NPSR1ALDH1A1MAPK1L3MBTL1HPGD | |
| SCHEMBL7541273 | 0.85 | NPSR1 (0.42) | NPSR1KDM4EALDH1A1S1PR4MAPK1 | |
| SCHEMBL7542243 | 0.84 | POLB (0.40) | KDM4EALDH1A1CCR4L3MBTL1EDNRA | |
| SCHEMBL5767143 | 0.83 | NPSR1 (0.58) | NPSR1KDM4EALDH1A1S1PR4MAPK1 | |
| SCHEMBL3170311 | 0.82 | POLB (0.42) | CCR4EDNRAPOLB | |
| SCHEMBL31214303 | 0.81 | NPSR1 (0.45) | NPSR1GAAKDM4EALDH1A1MAPK1 | |
| SCHEMBL31214143 | 0.81 | NPSR1 (0.45) | NPSR1KDM4EALDH1A1CCR4S1PR4 | |
| SCHEMBL5266763 | 0.81 | NPSR1 (0.45) | NPSR1GAAKDM4EALDH1A1MAPK1 | |
| SCHEMBL12248189 | 0.79 | NPSR1 (0.47) | NPSR1GAAKDM4EALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0889038-B1 | Process for the preparation of alkoxy-or aryloxypyrazine derivatives | LONZA AG (CH) | 2002-05-29 | — | — | EP | claimed |
| US-20010012894-A1 | Process for preparing alkoxypyrazine derivatives | FUCHS RUDOLF (CH) | 2001-08-09 | — | — | US | claimed |
| US-6235905-B1 | REACTING A GLYOXAL DERIVATIVE WITH A AMINOACETIMIDATE | LONZA AG (CH) | 2001-05-22 | — | — | US | claimed |
| US-6066736-A | Process for preparing alkoxypyrazine derivatives | LONZA AG (CH) | 2000-05-23 | — | — | US | claimed |
| US-6291674-B2 | REACTING GLYOXAL DERIVATIVE AND AMINOIMIDATE DERIVATIVE TO FORM 3-ALKOXY/ARYLOXY-5-(ALKYL/ARYL)PYRAZINE-2-CARBOXAMIDE; REACTING WITH ALKALI METAL HYPOHALITE TO FORM 3-ALKOXY/ARYLOXY-5-(ALKYL/ARYL)PYRAZINE-2-AMINE | LONZA AG (CH) | 2001-09-18 | — | — | US | disclosed |
| US-20010012894-A1 | Process for preparing alkoxypyrazine derivatives | FUCHS RUDOLF (CH) | 2001-08-09 | — | — | US | disclosed |
| US-6235905-B1 | REACTING A GLYOXAL DERIVATIVE WITH A AMINOACETIMIDATE | LONZA AG (CH) | 2001-05-22 | — | — | US | disclosed |
| US-6066736-A | Process for preparing alkoxypyrazine derivatives | LONZA AG (CH) | 2000-05-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010012894-A1 | Process for preparing alkoxypyrazine derivatives | CYP3A5, GMDS, CYP3A43 | NPSR1 2997/4885GAA 296/4885KDM4E 2279/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.