Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB1 | P46663 | 3/20 | 0.52 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.42 |
| ▸ | VNN1 | O95497 | 1/20 | 0.41 |
| ▸ | ACACB | O00763 | 8/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | ACACA | Q13085 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL765554 | 0.89 | BDKRB1 (0.67) | BDKRB1VNN1ACACBALDH1A1CNR1 | |
| SCHEMBL757026 | 0.82 | BDKRB1 (0.45) | BDKRB1CNR1 | |
| SCHEMBL14856694 | 0.82 | BDKRB1 (0.48) | BDKRB1FAAHTRPV1ACACBALDH1A1 | |
| SCHEMBL764514 | 0.80 | BDKRB1 (0.67) | BDKRB1ACACBCNR1ACACA | |
| SCHEMBL765602 | 0.78 | BDKRB1 (0.63) | BDKRB1ACACBCNR1ACACA | |
| SCHEMBL12239088 | 0.78 | BDKRB1 (0.63) | BDKRB1ACACBCNR1ACACA | |
| SCHEMBL3722413 | 0.78 | CACNA1I (0.37) | BDKRB1FAAHTRPV1VNN1ACACB | |
| SCHEMBL3725902 | 0.78 | CACNA1I (0.37) | BDKRB1FAAHTRPV1VNN1ACACB | |
| SCHEMBL765664 | 0.76 | CNR1 (0.56) | BDKRB1CNR1 | |
| SCHEMBL765825 | 0.76 | BDKRB1 (0.55) | BDKRB1ACACBCNR1ROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2188254-B1 | NOVEL BRADYKININ B1-ANTAGONISTS | BOEHRINGER INGELHEIM INT (DE) | 2012-03-21 | — | — | EP | disclosed |
| EP-2188254-A1 | NOVEL BRADYKININ B1-ANTAGONISTS | Boehringer Ingelheim International GmbH (DE) | 2010-05-26 | — | — | EP | disclosed |
| WO-2009027450-A1 | NOVEL BRADYKININ B1-ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-03-05 | — | — | WO | disclosed |