Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB3 | P13945 | 15/20 | 0.60 |
| ▸ | ADRB1 | P08588 | 6/20 | 0.49 |
| ▸ | ADRB2 | P07550 | 8/20 | 0.45 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | DRD2 | P14416 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | TLR4 | O00206 | 1/20 | 0.42 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.42 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.42 |
| ▸ | MLNR | O43193 | 1/20 | 0.42 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.42 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.42 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 1/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7226984 | 0.92 | ADRB3 (0.60) | ADRB3ADRB1ADRB2DNM1SLC6A2 | |
| SCHEMBL6986206 | 0.77 | ADRB3 (0.67) | ADRB3ADRB1ADRB2DNM1TLR4 | |
| SCHEMBL6985948 | 0.76 | ADRB3 (0.69) | ADRB3ADRB1ADRB2TLR4 | |
| SCHEMBL7138803 | 0.75 | ADRB3 (0.83) | ADRB3ADRB1ADRB2SLC6A2SLC6A4 | |
| SCHEMBL6980970 | 0.75 | ADRB3 (1.00) | ADRB3ADRB1ADRB2DNM1 | |
| SCHEMBL6986334 | 0.75 | ADRB3 (0.86) | ADRB3ADRB1ADRB2DNM1SLC6A2 | |
| SCHEMBL6982327 | 0.74 | ADRB3 (0.91) | ADRB3ADRB1ADRB2DNM1 | |
| SCHEMBL6074935 | 0.72 | ADRB3 (0.55) | ADRB3ADRB1ADRB2DNM1TLR4 | |
| SCHEMBL7133464 | 0.72 | ADRB3 (0.65) | ADRB3ADRB1ADRB2DNM1SLC6A2 | |
| SCHEMBL7542782 | 0.71 | ADRB3 (0.61) | ADRB3ADRB1ADRB2SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6498170-B2 | 4-((2S)-3-(1-(4-BUTOXY-BENZENESULFONYL)-AZETIDIN-3-YLAMINO)-2 -HYDROXY- PROPOXY)-PHENOL FOR EXAMPLE; HYPOGLYCEMIC AGENT; INCREASING LEAN MEAT TO FAT RATIO IN MAMMALS | WYETH | 2002-12-24 | — | — | US | disclosed |
| US-20020022605-A1 | Cyclamine sulfonamides as beta-3 adrenergic receptor agonists | AMERICAN HOME PRODUCTS CORPORATION (US) | 2002-02-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020022605-A1 | Cyclamine sulfonamides as beta-3 adrenergic receptor agonists | ADRB3, ADRB1, ADRB2 | ADRB3 1/4885ADRB1 2/4885ADRB2 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.