Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.59 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.59 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.59 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.59 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.59 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.59 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.59 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.59 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.59 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.59 |
| ▸ | MEN1 | O00255 | 3/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7549194 | 1.00 | HDAC8 (0.59) | HDAC8HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL7547276 | 1.00 | HDAC8 (0.59) | HDAC8HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL7543605 | 1.00 | HDAC8 (0.59) | HDAC8HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL2618100 | 1.00 | HDAC8 (0.59) | HDAC8HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL7589770 | 1.00 | HDAC8 (0.59) | HDAC8HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL9798508 | 1.00 | HDAC8 (0.59) | HDAC8HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL9798967 | 0.99 | ALDH1A1 (0.58) | HDAC8HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL7424373 | 0.94 | KMT2A (0.63) | KMT2AMEN1CYP1A2POLBCYP3A4 | |
| SCHEMBL12743156 | 0.92 | ALDH1A1 (0.54) | HDAC8HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL9761396 | 0.89 | HDAC8 (0.58) | HDAC8HDAC3HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0885886-B1 | PYRIDINECARBOXAMIDE DERIVATIVES | NISSHIN SEIFUN GROUP INC (JP) | 2002-05-29 | — | — | EP | disclosed |
| US-5972943-A | N-(NITRIC ACID,C14-18 ALKYL ESTER)-6-(1-(OPTIONALLY 4-SUBSTITUTED PIPERAZINYL)) PYRIDINE-3-CARBOXAMIDES; METHOD OF SYNTHESIS; ADMINISTERING TO TREAT CEREBRAL EDEMA; NO HYPOTENSIVE SIDE EFFECT | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1999-10-26 | — | — | US | disclosed |
| EP-0885886-A1 | NOVEL PYRIDINECARBOXAMIDE DERIVATIVES | Nisshin Flour Milling Co., Ltd. (JP) | 1998-12-23 | — | — | EP | disclosed |