Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.66 |
| ▸ | RAB9A | P51151 | 5/20 | 0.66 |
| ▸ | MAPT | P10636 | 4/20 | 0.66 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.66 |
| ▸ | HTT | P42858 | 1/20 | 0.66 |
| ▸ | ALOX5 | P09917 | 9/20 | 0.57 |
| ▸ | EPHX2 | P34913 | 9/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16044245 | 0.85 | NPC1 (0.62) | NPC1RAB9AMAPTL3MBTL1HTT | |
| SCHEMBL7544788 | 0.81 | NPC1 (0.68) | NPC1RAB9AMAPTL3MBTL1HTT | |
| SCHEMBL7548168 | 0.80 | ALOX5 (0.58) | NPC1RAB9AMAPTL3MBTL1HTT | |
| SCHEMBL10758257 | 0.80 | NPC1 (0.63) | NPC1RAB9AMAPTL3MBTL1HTT | |
| SCHEMBL7543356 | 0.80 | NPC1 (1.00) | NPC1RAB9AMAPTL3MBTL1HTT | |
| SCHEMBL7551610 | 0.79 | ALOX5 (0.57) | NPC1RAB9AMAPTL3MBTL1HTT | |
| SCHEMBL20103639 | 0.78 | NPC1 (0.70) | NPC1RAB9AMAPTL3MBTL1HTT | |
| SCHEMBL30354907 | 0.77 | EPHX2 (0.59) | NPC1RAB9AMAPTL3MBTL1HTT | |
| SCHEMBL29151274 | 0.77 | EPHX2 (0.59) | NPC1RAB9AMAPTL3MBTL1HTT | |
| SCHEMBL27452057 | 0.77 | NPC1 (0.81) | NPC1RAB9AMAPTL3MBTL1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018077898-A1 | N,N'-DIARYLUREA, N,N'-DIARYLTHIOUREA AND N,N'-DIARYLGUANIDINO COMPOUNDS FOR USE IN TREATMENT AND PREVENTION OF INFLAMMATORY DISEASE | UNIVERSITÄT INNSBRUCK (AT) | 2018-05-03 | — | — | WO | disclosed |
| EP-3315495-A1 | N,N' -DIARYLUREA, N,N' -DIARYLTHIOUREA AND N,N' -DIARYLGUANIDINO COMPOUNDS FOR USE IN TREATMENT AND PREVENTION OF INFLAMMATORY DISEASE | Universität Innsbruck (AT) | 2018-05-02 | — | — | EP | disclosed |
| EP-0795550-B1 | Aniline derivatives having herbicidal activity their preparation and their use | SANKYO CO (JP) | 2002-06-05 | — | — | EP | disclosed |
| CN-1073097-C | Aniline derivatives having herbicidal activity their prepn. and their use | SANKYO CO (JP) | 2001-10-17 | — | — | CN | disclosed |
| US-5736487-A | HERBICIDES | SANKYO COMPANY, LIMITED (JP) | 1998-04-07 | — | — | US | disclosed |
| CN-1176962-A | Aniline derivatives having herbicidal activity their prepn. and their use | SANKYO CO (JP) | 1998-03-25 | — | — | CN | disclosed |
| EP-0795550-A1 | Aniline derivatives having herbicidal activity their preparation and their use | SANKYO COMPANY LIMITED (JP) | 1997-09-17 | — | — | EP | disclosed |