Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 11/20 | 0.69 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.54 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.54 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.54 |
| ▸ | AHR | P35869 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.43 |
| ▸ | CLK1 | P49759 | 1/20 | 0.43 |
| ▸ | CLK2 | P49760 | 1/20 | 0.43 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL447519 | 0.84 | KMO (0.64) | KMOPIK3CAPIK3CBPIK3CGMAPT | |
| SCHEMBL19036732 | 0.81 | KMO (1.00) | KMOPIK3CAPIK3CBPIK3CGNPC1 | |
| SCHEMBL2402821 | 0.81 | KMO (0.65) | KMOPIK3CAPIK3CBPIK3CGAHR | |
| SCHEMBL28320772 | 0.79 | KMO (0.61) | KMOPIK3CAPIK3CBPIK3CGNPC1 | |
| SCHEMBL980557 | 0.78 | IDO1 (0.51) | KMOCLK4 | |
| SCHEMBL38657570 | 0.78 | IDO1 (0.51) | KMOCLK4 | |
| SCHEMBL12801571 | 0.78 | KMO (0.51) | KMOPIK3CAPIK3CBPIK3CGALDH1A1 | |
| SCHEMBL445861 | 0.78 | MEN1 (0.52) | KMONPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL441888 | 0.78 | MAPT (0.59) | KMOPIK3CAPIK3CBPIK3CGNPC1 | |
| SCHEMBL14742279 | 0.78 | KMO (0.59) | KMOPIK3CAPIK3CBPIK3CGAHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103841829-A | Certain kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions and methods of use thereof | CHDI FOUNDATION CORP | 2014-06-04 | — | — | CN | disclosed |
| US-6440984-B1 | PROTECTION FOR GROWING AND HARVESTED CROPS; CONTROLLING TOBACCO BUDWORMS AND SOUTHERN ARMYWORMS; PESTICIDES; INSECTICIDES; MITICIDES; ANTHELMINTICS | BASF AKTIENGESELLSCHAFT (DE) | 2002-08-27 | — | — | US | disclosed |
| US-20020045634-A1 | Use of aryl-substituted pyrimidines as insecticidal and acaricidal agents | AMERICAN CYANAMID COMPANY | 2002-04-18 | — | — | US | disclosed |
| US-6306866-B1 | 2-ALKOXY SUBSTITUTED PYRIMIDINE DERIVATIVES | AMERICAN CYANAMID COMPANY | 2001-10-23 | — | — | US | disclosed |
| US-6153619-A | Aryl-substituted pyrimidines as insecticidal and acaricidal agents | AMERICAN CYANAMID COMPANY (US) | 2000-11-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020045634-A1 | Use of aryl-substituted pyrimidines as insecticidal and acaricidal agents | YBX1, YBX3, CYP1B1 | KMO 1317/4885PIK3CA 1648/4885PIK3CB 1937/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.