Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 11/20 | 0.59 |
| ▸ | FLT1 | P17948 | 6/20 | 0.59 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.59 |
| ▸ | KIT | P10721 | 3/20 | 0.59 |
| ▸ | NAMPT | P43490 | 2/20 | 0.42 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.38 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5753928 | 0.82 | KDR (0.70) | KDRFLT1PDGFRBKITNAMPT | |
| SCHEMBL1652660 | 0.81 | KDR (0.69) | KDRFLT1PDGFRBKITNAMPT | |
| SCHEMBL1387032 | 0.76 | KDR (0.54) | KDRFLT1PDGFRBKITNAMPT | |
| SCHEMBL13955483 | 0.69 | KDR (0.70) | KDRFLT1PDGFRBKITCSNK2A1 | |
| SCHEMBL1383504 | 0.67 | KDR (0.44) | KDRFLT1PDGFRBKITNAMPT | |
| SCHEMBL1652015 | 0.65 | FLT1 (0.55) | KDRFLT1PDGFRBKITNAMPT | |
| SCHEMBL15052205 | 0.65 | KDR (0.63) | KDRFLT1PDGFRBKITCSNK2A1 | |
| SCHEMBL17432191 | 0.65 | MAPT (0.54) | KDRFLT1PDGFRBKITCSNK2A1 | |
| SCHEMBL8204447 | 0.64 | FLT1 (1.00) | KDRFLT1PDGFRBKITMEN1 | |
| SCHEMBL6505478 | 0.64 | FLT1 (0.67) | KDRFLT1PDGFRBKITMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165085-A1 | PHTHALAZINE DERIVATIVES FOR TREATING INFLAMMATORY DISEASES | Novartis AG (CH) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000059509-A1 | PHTHALAZINE DERIVATIVES FOR TREATING INFLAMMATORY DISEASES | NOVARTIS AG (CH) | 2000-10-12 | — | — | WO | disclosed |