Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 5/20 | 0.51 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.51 |
| ▸ | KIT | P10721 | 1/20 | 0.51 |
| ▸ | FLT1 | P17948 | 1/20 | 0.51 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.49 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | DHODH | Q02127 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17432143 | 0.93 | MAPT (0.51) | MAPTTP53RAPGEF4KDRPDGFRB | |
| SCHEMBL28744365 | 0.79 | RAPGEF4 (0.58) | MAPTTP53RAPGEF4KDRPDGFRB | |
| SCHEMBL11461554 | 0.79 | TP53 (0.52) | MAPTTP53KDRPDGFRBKIT | |
| SCHEMBL1998478 | 0.78 | KDR (0.63) | MAPTTP53RAPGEF4KDRMEN1 | |
| SCHEMBL11375683 | 0.78 | NPC1 (0.56) | MAPTTP53RAPGEF4KDRGRM4 | |
| SCHEMBL654408 | 0.74 | ALDH1A1 (0.47) | RAPGEF4KDRPDGFRBKITFLT1 | |
| SCHEMBL26545885 | 0.74 | RAPGEF4 (0.52) | MAPTTP53RAPGEF4KDRPDGFRB | |
| SCHEMBL265776 | 0.73 | RAPGEF4 (0.56) | RAPGEF4KDRPDGFRBKITFLT1 | |
| SCHEMBL654204 | 0.73 | SYK (0.60) | KDRFLT1AURKB | |
| SCHEMBL17432160 | 0.73 | ABCG2 (0.65) | MAPTTP53ALDH1A1LMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10189795-B2 | Aryl amine substituted quinoxaline used as anticancer drugs | Chen, Kuen-Feng (TW) | 2019-01-29 | — | — | US | disclosed |
| US-20170204071-A1 | ARYL AMINE SUBSTITUTED QUINOXALINE USED AS ANTICANCER DRUGS | SHIAU, CHUNG-WAI (TW) | 2017-07-20 | — | — | US | disclosed |
| US-20170204071-A1 | ARYL AMINE SUBSTITUTED QUINOXALINE USED AS ANTICANCER DRUGS | SHIAU, CHUNG-WAI (TW) | 2017-07-20 | — | — | US | disclosed |
| WO-2016004856-A1 | ARYL AMINE SUBSTITUTED QUINOXALINE USED AS ANTICANCER DRUGS | 陈昆锋 | 2016-01-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10189795-B2 | Aryl amine substituted quinoxaline used as anticancer drugs | CIP2A, PPP2CA, PPM1A | MAPT 3534/4885TP53 200/4885RAPGEF4 636/4885 |
| US-20170204071-A1 | ARYL AMINE SUBSTITUTED QUINOXALINE USED AS ANTICANCER DRUGS | CIP2A, PPP2CA, PPM1A | MAPT 3534/4885TP53 200/4885RAPGEF4 636/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.