Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | CTSD | P07339 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15467777 | 0.78 | CYP2D6 (0.36) | MAPTLMNANOTUMALDH1A1HSD17B10 | |
| SCHEMBL8619760 | 0.78 | ALDH1A1 (0.36) | MAPTLMNANOTUMSMN1; SMN2ALDH1A1 | |
| SCHEMBL8618657 | 0.78 | MAPK14 (0.39) | MAPTNOTUMMAPK14ALDH1A1NPC1 | |
| SCHEMBL5477527 | 0.73 | MAPT (0.43) | MAPTLMNANOTUMTP53CTSD | |
| SCHEMBL1498571 | 0.67 | KDM4E (0.48) | MAPTLMNATP53PKMSMN1; SMN2 | |
| SCHEMBL9728 | 0.64 | MAPT (1.00) | MAPTLMNANOTUMTP53CTSD | |
| SCHEMBL24625411 | 0.62 | MAPT (0.56) | MAPTLMNANOTUMTP53PDE3B | |
| SCHEMBL9120813 | 0.61 | MAPT (0.92) | MAPTLMNANOTUMTP53CTSD | |
| Hydrochloric Acid SCHEMBL5548691 | 0.61 | MAPT (0.92) | MAPTLMNANOTUMTP53CTSD | |
| SCHEMBL135626 | 0.61 | MAPT (0.92) | MAPTLMNANOTUMTP53PDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4405628-A | 4-Pyridylimidazolones and method of use | MERRELL DOW PHARMACEUTICALS INC. (US) | 1983-09-20 | — | — | US | disclosed |