Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 8/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.33 |
| ▸ | BAD | Q92934 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | USP1 | O94782 | 1/20 | 0.33 |
| ▸ | USP19 | O94966 | 1/20 | 0.33 |
| ▸ | UCHL3 | P15374 | 1/20 | 0.33 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.32 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.32 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.31 |
| ▸ | TNKS | O95271 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28186290 | 0.79 | ALDH1A1 (0.34) | RAB9ANPC1MAPTALDH1A1TNKS | |
| SCHEMBL15467777 | 0.79 | CYP2D6 (0.36) | NOTUMRAB9ANPC1MAPTALDH1A1 | |
| SCHEMBL28211241 | 0.79 | NOTUM (0.37) | NOTUMRAB9AALDH1A1 | |
| SCHEMBL7545259 | 0.78 | MAPT (0.43) | MAPK14NOTUMRAB9ANPC1MAPT | |
| SCHEMBL28238007 | 0.73 | PTPN1 (0.38) | AR | |
| SCHEMBL27541518 | 0.67 | NOTUM (0.35) | NOTUM | |
| SCHEMBL8618979 | 0.67 | MAPK14 (0.39) | MAPK14NOTUMRAB9ANPC1MAPT | |
| SCHEMBL6168373 | 0.65 | MAPK14 (0.55) | MAPK14MAPK10AR | |
| SCHEMBL8623934 | 0.64 | — | — | |
| SCHEMBL866248 | 0.62 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107922345-A | Arylsulfonamide compounds and its therapeutical uses as carbonic anhydrase inhibitor | 圣诺康生命科学公司 | 2018-04-17 | — | — | CN | claimed |
| CN-108349984-A | The derivative of 1- Phenylpyrrolidine -2- ketone as PERK inhibitor | 葛兰素史密斯克莱知识产权（第2 号）有限公司 | 2018-07-31 | — | — | CN | disclosed |
| CN-107922345-A | Arylsulfonamide compounds and its therapeutical uses as carbonic anhydrase inhibitor | 圣诺康生命科学公司 | 2018-04-17 | — | — | CN | disclosed |
| US-5849861-A | Polyquinazolines and methods for their preparation | HITACHI CHEMICAL CO., LTD. (JP) | 1998-12-15 | — | — | US | disclosed |
| US-5686560-A | TREATING A MONOMER WITH A BASE IN A DIPOLAR SOLVENT | HITACHI CHEMICAL CO., LTD. (JP) | 1997-11-11 | — | — | US | disclosed |