SCHEMBL7545359

SCHEMBL7545359

O=[N+]([O-])c1ccc(/N=N/C(c2ccccc2)(c2ccccc2)c2ccccc2)cc1.c1ccc(/N=N/C(c2ccccc2)(c2ccccc2)c2ccccc2)cc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 7/20 0.53
KMT2A Q03164 7/20 0.53
ALDH1A1 P00352 6/20 0.53
RAB9A P51151 5/20 0.53
MAPT P10636 5/20 0.53
SMN1; SMN2 Q16637 3/20 0.53
MAPK1 P28482 3/20 0.53
CASP3 P42574 1/20 0.53
SENP8 Q96LD8 1/20 0.53
SENP7 Q9BQF6 1/20 0.53
SENP6 Q9GZR1 1/20 0.53
NPC1 O15118 4/20 0.50
TNNI3 P19429 1/20 0.50
TNNT2 P45379 1/20 0.50
TNNC1 P63316 1/20 0.50
KEAP1 Q14145 1/20 0.50
NFE2L2 Q16236 1/20 0.50
LMNA P02545 2/20 0.47
TDP1 Q9NUW8 2/20 0.42
CYP19A1 P11511 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7545364 1.00 MEN1 (0.53) MEN1KMT2AALDH1A1RAB9AMAPT
SCHEMBL491696 0.98 MEN1 (0.54) MEN1KMT2AALDH1A1RAB9AMAPT
SCHEMBL491695 0.98 MEN1 (0.54) MEN1KMT2AALDH1A1RAB9AMAPT
SCHEMBL11803383 0.92 RAB9A (0.50) MEN1KMT2AALDH1A1RAB9AMAPT
SCHEMBL270425 0.82 MEN1 (0.66) MEN1KMT2AALDH1A1RAB9AMAPT
SCHEMBL270426 0.82 MEN1 (0.66) MEN1KMT2AALDH1A1RAB9AMAPT
SCHEMBL29588234 0.82 MEN1 (0.66) MEN1KMT2AALDH1A1RAB9AMAPT
Hydrochloric Acid SCHEMBL28545676 0.81 MEN1 (0.64) MEN1KMT2AALDH1A1RAB9AMAPT
Methane SCHEMBL5133892 0.81 ALDH1A1 (0.64) MEN1KMT2AALDH1A1RAB9AMAPT
SCHEMBL491314 0.80 ALDH1A1 (0.52) MEN1KMT2AALDH1A1RAB9AMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20020133072-A1 Graft polymerization of substrate surfaces ANGIOTECH BIOCOATINGS CORP. 2002-09-19 US claimed
EP-1214107-A1 GRAFT POLYMERIZATION OF SUBSTRATE SURFACES STS Biopolymers, Inc. (US) 2002-06-19 EP claimed
US-6358557-B1 EXPOSING A SUBSTRATE TO AN INITIATOR IN SOLUTION TO GENERATE REACTIVE RADICAL SITES ON THE SURFACE OF THE SUBSTRATE; CONTACTING WITH MONOMERS; GRAFT POLYMERIZING ONTO SUBSTRATE BY FORMING COVALENT BONDS BETWEEN MONOMER MOLECULES AND SUBSTRATE STS BIOPOLYMERS, INC. 2002-03-19 US claimed
WO-2001017575-A1 GRAFT POLYMERIZATION OF SUBSTRATE SURFACES STS BIOPOLYMERS, INC. (US) 2001-03-15 WO claimed