Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.50 |
| ▸ | GRM6 | O15303 | 5/20 | 0.50 |
| ▸ | GAA | P10253 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6822486 | 0.88 | GRM6 (0.54) | MAPTALDH1A1GRM6GAAHPGD | |
| SCHEMBL7012400 | 0.85 | MAPT (0.47) | MAPTALDH1A1GAASMN1; SMN2RAB9A | |
| SCHEMBL7519571 | 0.84 | LIMK1 (0.49) | MAPTALDH1A1GRM6GAAHPGD | |
| SCHEMBL7008787 | 0.82 | ALDH1A1 (0.52) | MAPTALDH1A1GAAHPGDSMN1; SMN2 | |
| SCHEMBL11581714 | 0.81 | KDM4E (0.48) | MAPTALDH1A1GAAHPGDSMN1; SMN2 | |
| SCHEMBL7518124 | 0.81 | LIMK1 (0.46) | MAPTALDH1A1GRM6GAAHPGD | |
| SCHEMBL7013153 | 0.80 | ALDH1A1 (0.45) | MAPTALDH1A1GAAHPGDNPSR1 | |
| SCHEMBL7013822 | 0.79 | KDM4E (0.41) | MAPTALDH1A1GAAHPGDLMNA | |
| SCHEMBL1269832 | 0.79 | GABRP (0.52) | MAPTALDH1A1GAANPSR1SMN1; SMN2 | |
| SCHEMBL11666684 | 0.76 | ALDH1A1 (0.64) | MAPTALDH1A1HPGDSMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0781774-B1 | Prolactin production inhibitory agents | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2002-07-31 | — | — | EP | disclosed |
| US-6015789-A | LUTEINIZING HORMONE RELEASING HORMONE AGONIST AND A LUTEINIZING HORMONE RELEASING HORMONE ANTAGONIST IN COMBINATION, | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2000-01-18 | — | — | US | disclosed |
| US-5977132-A | GALACTORRHEA, HYPERPROLACTINEMIC OVULATION, PROLACTINOMA AND BRAIN TUMORS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1999-11-02 | — | — | US | disclosed |
| EP-0906115-A1 | COMBINED USE OF GnRH AGONIST AND ANTAGONIST | Takeda Chemical Industries, Ltd. (JP) | 1999-04-07 | — | — | EP | disclosed |
| EP-0862573-A1 | THIENOPYRIDINE DERIVATIVES AS GONADOTROPIN RELEASING HORMONE ANTAGONISTS | Takeda Chemical Industries, Ltd. (JP) | 1998-09-09 | — | — | EP | disclosed |
| US-5744479-A | PITUITARY HORMONE INHIBITOR | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-04-28 | — | — | US | disclosed |
| WO-1997040846-A1 | COMBINED USE OF GnRH AGONIST AND ANTAGONIST | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-11-06 | — | — | WO | disclosed |
| EP-0781774-A2 | Prolactin production inhibitory agents | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-07-02 | — | — | EP | disclosed |
| WO-1997014697-A1 | THIENOPYRIDINE DERIVATIVES AS GONADOTROPIN RELEASING HORMONE ANTAGONISTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-04-24 | — | — | WO | disclosed |