Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 3/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.42 |
| ▸ | DRD2 | P14416 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | ACHE | P22303 | 2/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7545783 | 1.00 | MTNR1A (0.42) | MTNR1AMTNR1BDRD2KMT2AL3MBTL1 | |
| SCHEMBL7545412 | 0.93 | MTNR1A (0.45) | MTNR1AMTNR1BDRD2KMT2AL3MBTL1 | |
| SCHEMBL7545419 | 0.93 | MTNR1A (0.45) | MTNR1AMTNR1BDRD2KMT2AL3MBTL1 | |
| SCHEMBL9132654 | 0.85 | MTNR1A (0.40) | MTNR1AMTNR1BDRD2CA1CA2 | |
| SCHEMBL5722255 | 0.83 | MTNR1A (0.50) | MTNR1AMTNR1BDRD2CA1CA2 | |
| SCHEMBL5722257 | 0.83 | MTNR1A (0.50) | MTNR1AMTNR1BDRD2CA1CA2 | |
| SCHEMBL9133425 | 0.82 | MTNR1A (0.42) | MTNR1AMTNR1BDRD2CA1CA2 | |
| SCHEMBL9136926 | 0.82 | MTNR1A (0.42) | MTNR1AMTNR1BDRD2CA1CA2 | |
| SCHEMBL9130726 | 0.82 | MTNR1A (0.42) | MTNR1AMTNR1BDRD2CA1CA2 | |
| SCHEMBL9137396 | 0.81 | MTNR1A (0.46) | MTNR1AMTNR1BDRD2KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0894787-B1 | 3,4-DISUBSTITUTED PHENYLETHANOLAMINOTETRALINCARBOXYLATE DERIVATIVES | KISSEI PHARMACEUTICAL (JP) | 2002-06-12 | — | — | EP | disclosed |
| US-6136852-A | 3,4-disubstituted phenylethanolaminotetralincarboxylic acid derivatives | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2000-10-24 | — | — | US | disclosed |
| EP-0894787-A1 | 3,4-DISUBSTITUTED PHENYLETHANOLAMINOTETRALINCARBOXYLATE DERIVATIVES | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 1999-02-03 | — | — | EP | disclosed |