Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 3/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.42 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.41 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 5/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | ACHE | P22303 | 2/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | CASR | P41180 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9133425 | 1.00 | MTNR1A (0.42) | MTNR1AMTNR1BCYP4F2CYP4A11DRD2 | |
| SCHEMBL9136926 | 1.00 | MTNR1A (0.42) | MTNR1AMTNR1BCYP4F2CYP4A11DRD2 | |
| SCHEMBL9132654 | 0.94 | MTNR1A (0.40) | MTNR1AMTNR1BDRD2CA1CA2 | |
| SCHEMBL7545412 | 0.87 | MTNR1A (0.45) | MTNR1AMTNR1BDRD2CA1CA2 | |
| SCHEMBL7545419 | 0.87 | MTNR1A (0.45) | MTNR1AMTNR1BDRD2CA1CA2 | |
| SCHEMBL9133100 | 0.84 | DRD2 (0.43) | CYP4F2CYP4A11DRD2CASRDRD3 | |
| SCHEMBL7545783 | 0.82 | MTNR1A (0.42) | MTNR1AMTNR1BDRD2CA1CA2 | |
| SCHEMBL7545778 | 0.82 | MTNR1A (0.42) | MTNR1AMTNR1BDRD2CA1CA2 | |
| SCHEMBL9672071 | 0.82 | CYP4F2 (0.43) | CYP4F2CYP4A11DRD2CASREPHX2 | |
| SCHEMBL9681375 | 0.82 | CYP4F2 (0.39) | CYP4F2CYP4A11DRD2CASRDRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5449813-A | Phenylethanolamino- and phenylethanolaminomethyl-tetralines, process for the preparation thereof, intermediates in said process and pharmaceutical compositions containing them | SANOFI (FR) | 1995-09-12 | — | — | US | disclosed |
| EP-0500443-B1 | Phenylethanolamino- and phenylethanolaminomethyltetralines, process for their preparation, intermediates of this process and pharmaceutical compositions containing them | SANOFI SA (FR) | 1995-04-26 | — | — | EP | disclosed |
| US-5401879-A | Phenylethanolamino- and phenylethanolaminomethyltetralines, process for the preparation thereof, intermediates in said process and pharmaceutical compositions containing them | SANOFI (FR) | 1995-03-28 | — | — | US | disclosed |
| US-5210276-A | PHENYLETHANOLAMINO- AND PHENYLETHANOLAMINOMETHYL-TETRALINES, PROCESS FOR THE PREPARATION THEREOF, INTERMEDIATES IN SAID PROCESS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ELF SANOFI (FR) | 1993-05-11 | — | — | US | disclosed |
| EP-0500443-A1 | Phenylethanolamino- and phenylethanolaminomethyltetralines, process for their preparation, intermediates of this process and pharmaceutical compositions containing them | SANOFI (FR) | 1992-08-26 | — | — | EP | disclosed |