Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 9/20 | 0.48 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | PRKCI | P41743 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
| ▸ | FDPS | P14324 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4429215 | 0.88 | TBXAS1 (0.60) | TBXAS1EGLN3CYP19A1PRKCICYP11B1 | |
| SCHEMBL9035805 | 0.79 | TBXAS1 (0.54) | TBXAS1EGLN3CYP19A1PRKCICYP11B1 | |
| SCHEMBL9035987 | 0.73 | TBXAS1 (0.76) | TBXAS1 | |
| SCHEMBL574077 | 0.72 | — | — | |
| SCHEMBL28726885 | 0.72 | — | — | |
| SCHEMBL2001148 | 0.72 | — | — | |
| SCHEMBL6157080 | 0.72 | — | — | |
| SCHEMBL4773938 | 0.72 | TBXAS1 (0.75) | TBXAS1EGLN3CYP19A1PRKCICYP11B1 | |
| SCHEMBL27342892 | 0.71 | KDM4E (0.48) | TBXAS1EGLN3 | |
| Hydrochloric Acid SCHEMBL25239361 | 0.71 | TBXAS1 (0.54) | TBXAS1EGLN3FDPS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1178967-A1 | QUINOLINE DERIVATIVES AS INHIBITORS OF MEK ENZYMES | AstraZeneca AB (SE) | 2002-02-13 | — | — | EP | disclosed |
| WO-2000068201-A1 | QUINOLINE DERIVATIVES AS INHIBITORS OF MEK ENZYMES | ASTRAZENECA AB (SE) | 2000-11-16 | — | — | WO | disclosed |