Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 12/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 7/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.45 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.45 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.45 |
| ▸ | GRM6 | O15303 | 1/20 | 0.45 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.44 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1955746 | 0.85 | SLC6A3 (0.71) | SLC6A3SLC6A2SLC6A4 | |
| SCHEMBL6489548 | 0.85 | SLC6A3 (0.54) | SLC6A3SLC6A2SLC6A4CHRM2CHRM4 | |
| SCHEMBL6490853 | 0.84 | SLC6A3 (0.55) | SLC6A3SLC6A2SLC6A4CHRM2CHRM4 | |
| SCHEMBL6490857 | 0.84 | SLC6A3 (0.55) | SLC6A3SLC6A2SLC6A4CHRM2CHRM4 | |
| SCHEMBL1743636 | 0.82 | SLC6A3 (0.71) | SLC6A3SLC6A2SLC6A4CHRM5CHRM1 | |
| SCHEMBL16061721 | 0.82 | SLC6A3 (0.64) | SLC6A3SLC6A2SLC6A4CHRM2CHRM4 | |
| SCHEMBL6161883 | 0.82 | SLC6A3 (0.48) | SLC6A3SLC6A2SLC6A4CHRM2CHRM4 | |
| SCHEMBL21332404 | 0.81 | SLC6A3 (0.72) | SLC6A3SLC6A2SLC6A4CHRM5CHRM1 | |
| SCHEMBL6503784 | 0.81 | SLC6A2 (0.56) | SLC6A3SLC6A2SLC6A4CHRM2CHRM4 | |
| SCHEMBL17474599 | 0.81 | SLC6A2 (0.68) | SLC6A3SLC6A2SLC6A4CHRM2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1041989-A4 | NOVEL CYCLOALKENYL SUBSTITUTED COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2002-11-20 | — | — | EP | disclosed |
| US-6362193-B1 | ANTIINFLAMMATORY AGENTS | SMITHKLINE BEECHAM CORPORATION | 2002-03-26 | — | — | US | disclosed |
| EP-1041989-A1 | NOVEL CYCLOALKENYL SUBSTITUTED COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-10-11 | — | — | EP | disclosed |
| WO-1999017776-A1 | NOVEL CYCLOALKENYL SUBSTITUTED COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-04-15 | — | — | WO | disclosed |