SCHEMBL7546086

SCHEMBL7546086

CCCCOc1cn[c]nc1-c1ccccn1

nearest known ligand 0.50

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
CYP2C9 P11712 4/20 0.50
CYP2C19 P33261 4/20 0.50
CYP1A2 P05177 3/20 0.50
CYP19A1 P11511 3/20 0.50
CYP2D6 P10635 2/20 0.50
TLR8 Q9NR97 1/20 0.38
PDE5A O76074 1/20 0.36
PDE4A P27815 1/20 0.36
PDE4B Q07343 1/20 0.36
PDE4C Q08493 1/20 0.36
PDE4D Q08499 1/20 0.36
ADORA2A P29274 1/20 0.35
ADORA1 P30542 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7547642 0.87 CBFB (0.42) CYP2C9CYP2C19CYP1A2CYP19A1CYP2D6
SCHEMBL4720917 0.82 ATP4A (0.42) CYP2C9CYP2C19CYP1A2CYP19A1CYP2D6
SCHEMBL558176 0.81 SMN1; SMN2 (0.48) CYP2C19CYP1A2CYP2D6
SCHEMBL7546903 0.81 TRPM8 (0.40) CYP2C9CYP2C19CYP1A2CYP19A1CYP2D6
SCHEMBL7544593 0.78 TRPM8 (0.45) CYP1A2TLR8ADORA1
SCHEMBL7550311 0.78 KDM4E (0.36) CYP1A2
SCHEMBL4723469 0.75 HTR1B (0.46) CYP2C9CYP2C19CYP1A2CYP19A1TLR8
SCHEMBL4721963 0.74 TLR8 (0.39) TLR8
SCHEMBL20985616 0.71 KDM4E (0.45) CYP1A2
SCHEMBL558611 0.70 KDM4E (0.43) CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2002043680-A1 FIXATION OF CARBOHYDRATES TO FIBROUS MATERIALS HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) 2002-06-06 WO disclosed
WO-2002043678-A2 ENZYMATIC FIXATION OF DERIVATISED CARBOHYDRATES TO FIBROUS MATERIALS HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) 2002-06-06 WO disclosed