Trifluoroacetic Acid

Trifluoroacetic Acid

SCHEMBL7546206

CCn1nc(Cc2ccccc2)cc1C1CCNCC1.O=C(O)C(F)(F)F

nearest known ligand 0.49

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Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
CCR5 P51681 19/20 0.49
KCNH2 Q12809 3/20 0.47
ARG1 P05089 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Trifluoroacetic Acid SCHEMBL5764463 1.00 CCR5 (0.49) CCR5KCNH2ARG1
SCHEMBL5456417 0.90 CCR5 (0.48) CCR5KCNH2ARG1
Hydrochloric Acid SCHEMBL5765781 0.89 GABRA1 (0.48) CCR5KCNH2ARG1
Hydrochloric Acid SCHEMBL5764233 0.89 GABRA1 (0.48) CCR5KCNH2ARG1
SCHEMBL5763925 0.83 CCR5 (0.47) CCR5KCNH2
SCHEMBL5765780 0.82 CCR5 (0.47) CCR5KCNH2
SCHEMBL5763121 0.82 SLC6A2 (0.50) CCR5
SCHEMBL5762825 0.81 GABRA1 (0.43) CCR5KCNH2
Hydrochloric Acid SCHEMBL7661969 0.81 CCR5 (0.46) CCR5KCNH2
Hydrochloric Acid SCHEMBL5762232 0.81 CCR5 (0.46) CCR5KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1171122-A4 PYRROLIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY MERCK & CO INC (US) 2002-05-29 EP disclosed
EP-1171122-A1 PYRROLIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY Merck & Co., Inc. (US) 2002-01-16 EP disclosed
US-6248755-B1 ANTIINFLAMMATORY AGENTS; ANTIALLERGENS; AUTOIMMUNE DISEASES MERCK & CO., INC. 2001-06-19 US disclosed
WO-2000059502-A1 PYRROLIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY MERCK & CO., INC. (US) 2000-10-12 WO disclosed