Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Proline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 3/20 | 0.47 |
| ▸ | SCN4A | P35499 | 1/20 | 0.44 |
| ▸ | CTSC | P53634 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ELANE | P08246 | 1/20 | 0.42 |
| ▸ | DPP4 | P27487 | 1/20 | 0.41 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.41 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.41 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
| ▸ | NOS2 | P35228 | 2/20 | 0.41 |
| ▸ | NOS3 | P29474 | 1/20 | 0.41 |
| ▸ | NOS1 | P29475 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 2/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Biphenyl SCHEMBL2308811 | 0.92 | ELANE (0.47) | HTR2CSCN4ACTSCMEN1BLM | |
| Proline SCHEMBL16394427 | 0.87 | BLM (0.48) | SCN4ACTSCMEN1BLMKMT2A | |
| Proline SCHEMBL10141181 | 0.87 | — | — | |
| D-Proline SCHEMBL21462052 | 0.87 | BLM (0.52) | MEN1BLMKMT2ADPP4DPP8 | |
| Proline SCHEMBL2939 | 0.87 | — | — | |
| Proline SCHEMBL462225 | 0.87 | BLM (0.52) | MEN1BLMKMT2ADPP4DPP8 | |
| Proline SCHEMBL10141185 | 0.87 | — | — | |
| Proline SCHEMBL718906 | 0.87 | BLM (0.52) | MEN1BLMKMT2ADPP4DPP8 | |
| Proline SCHEMBL13248912 | 0.87 | — | — | |
| Proline SCHEMBL462226 | 0.87 | BLM (0.52) | MEN1BLMKMT2ADPP4DPP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024018471-A1 | CATHEPSIN INHIBITORS AND USE THEREOF IN A METHOD FOR DETECTING AND TREATING RESISTANCE TO IMMUNOTHERAPY | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. (IL) | 2024-01-25 | — | — | WO | disclosed |
| WO-2023166511-A1 | IONIZABLE LIPIDS AND COMPOSITIONS COMPRISING SAME | BARCODE NANOTECH LTD. (IL) | 2023-09-07 | — | — | WO | disclosed |
| WO-2002055112-A2 | POLYPODAL CHELANTS FOR METALLOPHARMACEUTICALS | BRISTOL MYERS SQUIBB CO (US) | 2002-07-18 | — | — | WO | disclosed |