Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC1 | P33527 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6945541 | 0.95 | MAPK1 (0.35) | MAPK1 | |
| SCHEMBL6952784 | 0.93 | GAA (0.35) | GAA | |
| SCHEMBL6952693 | 0.93 | MAPT (0.35) | LMNAHTTALDH1A1 | |
| SCHEMBL6951129 | 0.93 | MEN1 (0.39) | — | |
| SCHEMBL7489535 | 0.91 | CYP2D6 (0.36) | MAPK1 | |
| SCHEMBL6947134 | 0.89 | ALDH1A1 (0.38) | MAPK1ALDH1A1 | |
| SCHEMBL6947977 | 0.89 | MAPK1 (0.38) | LMNAMAPK1 | |
| SCHEMBL6946334 | 0.88 | MMP13 (0.36) | — | |
| SCHEMBL6949316 | 0.86 | ALDH1A1 (0.35) | MAPK1ALDH1A1 | |
| SCHEMBL6944762 | 0.86 | ALDH1A1 (0.37) | LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1254118-A2 | SUBSTITUTED 1,2,3,4- TETRAHYDROQUINOLINE-2-CARBOXYLIC ACID DERIVATIVES | Grünenthal GmbH (DE) | 2002-11-06 | — | — | EP | disclosed |
| WO-2001058875-A2 | SUBSTITUTED 1,2,3,4- TETRAHYDROQUINOLINE-2-CARBOXYLIC ACID DERIVATIVES | Grünenthal GmbH (DE) | 2001-08-16 | — | — | WO | disclosed |