Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.55 |
| ▸ | ADRA1A | P35348 | 6/20 | 0.51 |
| ▸ | ADRA2A | P08913 | 5/20 | 0.51 |
| ▸ | ADRA2B | P18089 | 5/20 | 0.51 |
| ▸ | ADRA2C | P18825 | 5/20 | 0.51 |
| ▸ | ADRA1D | P25100 | 5/20 | 0.51 |
| ▸ | ADRA1B | P35368 | 5/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7452042 | 0.88 | HIF1A (0.56) | ADRA1AADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL7567774 | 0.83 | ADORA3 (0.51) | ADORA3TSHRMEN1KMT2AALDH1A1 | |
| SCHEMBL7543877 | 0.78 | MAPT (0.49) | ADORA3ADRA1AADRA2AADRA2BADRA2C | |
| SCHEMBL7508983 | 0.76 | HIF1A (0.52) | TSHRMEN1KMT2APOLBHIF1A | |
| SCHEMBL10666185 | 0.76 | MEN1 (0.69) | ADORA3TDP1TSHRMEN1KMT2A | |
| SCHEMBL16137718 | 0.75 | TSHR (0.70) | ADORA3TSHRMEN1KMT2AALDH1A1 | |
| SCHEMBL7160123 | 0.75 | ADORA3 (0.85) | ADORA3ADRA1AADRA2AADRA2BADRA2C | |
| SCHEMBL7391021 | 0.74 | ADORA3 (0.53) | ADORA3ADRA1ATDP1TSHRMEN1 | |
| SCHEMBL7445582 | 0.73 | HIF1A (0.59) | TSHRMEN1KMT2APOLBHIF1A | |
| SCHEMBL7358894 | 0.73 | TSHR (0.67) | ADORA3TSHRMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1995013812-A1 | USE OF SUBSTITUTED 1,4-DIHYDROPYRIDINE TO REDUCE INTRAOCULAR PRESSURE | BYK NEDERLAND BV (NL) | 1995-05-26 | — | — | WO | claimed |
| US-5378718-A | Cardiovascular activity, hypotensive | CEDONA PHARMACEUTICALS B.V. (NL) | 1995-01-03 | — | — | US | disclosed |