Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.54 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.54 |
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | IGF1R | P08069 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | C3AR1 | Q16581 | 1/20 | 0.41 |
| ▸ | AGXT | P21549 | 2/20 | 0.41 |
| ▸ | CHKA | P35790 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | DAO | P14920 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL7548936 | 0.85 | CYP1A2 (0.50) | CYP1A2CYP2A6TAAR1IDO1KCNH2 | |
| SCHEMBL11288839 | 0.80 | CYP1A2 (0.68) | CYP1A2CYP2A6TAAR1IDO1KCNH2 | |
| SCHEMBL143961 | 0.80 | CYP1A2 (0.68) | CYP1A2CYP2A6TAAR1IDO1KCNH2 | |
| SCHEMBL6546878 | 0.75 | CYP1A2 (0.62) | CYP1A2CYP2A6TAAR1IDO1KCNH2 | |
| SCHEMBL6546754 | 0.75 | IGF1R (0.64) | CYP1A2CYP2A6TAAR1IDO1KCNH2 | |
| Iodide SCHEMBL7548535 | 0.74 | ESR1 (0.65) | TAAR1TDP1ACHEIGF1RALOX15 | |
| Iodide SCHEMBL7545274 | 0.74 | TAAR1 (0.54) | TAAR1IDO1C3AR1AGXTL3MBTL1 | |
| Iodide SCHEMBL7546993 | 0.74 | TSHR (0.43) | TAAR1TDP1CHKAALDH1A1L3MBTL1 | |
| Iodide SCHEMBL7547744 | 0.73 | ALDH1A1 (0.56) | HRH3TDP1ALOX15CHKAALDH1A1 | |
| SCHEMBL10571160 | 0.72 | IGF1R (0.61) | CYP1A2CYP2A6TAAR1IDO1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6482990-B1 | Prostaglandin E analogues | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2002-11-19 | — | — | US | disclosed |
| EP-1211241-A1 | PROSTAGLANDIN E ANALOGUES | TAISHO PHARMACEUTICAL CO., LTD (JP) | 2002-06-05 | — | — | EP | disclosed |