Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 11/20 | 0.60 |
| ▸ | CYP19A1 | P11511 | 7/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.58 |
| ▸ | ESR2 | Q92731 | 6/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.56 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.56 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.56 |
| ▸ | EGFR | P00533 | 1/20 | 0.56 |
| ▸ | GBA1 | P04062 | 1/20 | 0.56 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.56 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | PRKCG | P05129 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | PRKCB | P05771 | 1/20 | 0.56 |
| ▸ | LCK | P06239 | 1/20 | 0.56 |
| ▸ | FYN | P06241 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7547707 | 1.00 | ESR1 (0.60) | ESR1CYP19A1CYP3A4ESR2MAPT | |
| SCHEMBL10798831 | 0.86 | ESR1 (0.59) | ESR1CYP19A1CYP3A4ESR2MAPT | |
| SCHEMBL10798818 | 0.86 | ESR1 (0.59) | ESR1CYP19A1CYP3A4ESR2MAPT | |
| SCHEMBL7654135 | 0.86 | ESR1 (0.59) | ESR1CYP19A1CYP3A4ESR2MAPT | |
| SCHEMBL25407318 | 0.84 | ESR1 (0.71) | ESR1CYP19A1CYP3A4ESR2MAPT | |
| SCHEMBL7723737 | 0.84 | LMNA (0.59) | ESR1CYP19A1CYP3A4ESR2HTR6 | |
| SCHEMBL227233 | 0.84 | ESR1 (0.59) | ESR1CYP19A1CYP3A4ESR2MAPT | |
| SCHEMBL1962745 | 0.84 | ESR1 (0.59) | ESR1CYP19A1CYP3A4ESR2MAPT | |
| SCHEMBL15649793 | 0.84 | LMNA (0.59) | ESR1CYP19A1CYP3A4ESR2HTR6 | |
| SCHEMBL8500019 | 0.84 | LMNA (0.59) | ESR1CYP19A1CYP3A4ESR2HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1212120-A2 | METHODS AND COMPOSITIONS CONTAINING SUCCINIMIDE OR MALEIMIDE DERIVATIVES OF ANTINEOPLASTIC AGENTS, FOR PRODUCING LONG LASTING ANTINEOPLASTIC AGENTS | Conjuchem, Inc. (CA) | 2002-06-12 | — | — | EP | disclosed |
| WO-2001017614-A2 | METHODS AND COMPOSITIONS CONTAINING SUCCINIMIDE OR MALEIMIDE DERIVATIVES OF ANTINEOPLASTIC AGENTS | CONJUCHEM, INC. (CA) | 2001-03-15 | — | — | WO | disclosed |