Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | HTR6 | P50406 | 1/20 | 0.59 |
| ▸ | ESR1 | P03372 | 10/20 | 0.54 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.54 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.54 |
| ▸ | ESRRG | P62508 | 4/20 | 0.54 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | ESRRB | O95718 | 1/20 | 0.42 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.41 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.41 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7723737 | 1.00 | LMNA (0.59) | LMNAHTR6ESR1ESR2CYP19A1 | |
| SCHEMBL15649793 | 1.00 | LMNA (0.59) | LMNAHTR6ESR1ESR2CYP19A1 | |
| SCHEMBL5739365 | 0.95 | LMNA (0.54) | LMNAHTR6ESR1ESR2CYP19A1 | |
| SCHEMBL906294 | 0.87 | LMNA (0.57) | LMNAHTR6ESR1ESR2CYP19A1 | |
| SCHEMBL9098763 | 0.87 | LMNA (0.57) | LMNAHTR6ESR1ESR2CYP19A1 | |
| SCHEMBL906290 | 0.87 | LMNA (0.57) | LMNAHTR6ESR1ESR2CYP19A1 | |
| SCHEMBL7547707 | 0.84 | ESR1 (0.60) | HTR6ESR1ESR2CYP19A1ESRRG | |
| SCHEMBL7547715 | 0.84 | ESR1 (0.60) | HTR6ESR1ESR2CYP19A1ESRRG | |
| SCHEMBL17506017 | 0.82 | LMNA (0.64) | LMNAHTR6ESR1ESR2CYP19A1 | |
| SCHEMBL17506015 | 0.82 | LMNA (0.64) | LMNAHTR6ESR1ESR2CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5912273-A | COMPOUNDS WITH CHLORO AND HYDROXY GROUPS FOR OSTEOPOROSIS | ORION-YHTYMA OY (FI) | 1999-06-15 | — | — | US | disclosed |
| US-5750576-A | BONE DISORDERS | ORION-YHTYMA OY (FI) | 1998-05-12 | — | — | US | disclosed |