Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 5/20 | 0.55 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7488308 | 0.85 | CCNB2 (0.53) | HTR6NR1H2PTGS1PTGS2HSD17B10 | |
| SCHEMBL28883032 | 0.82 | TSHR (0.55) | HSD17B10TSHRALDH1A1KDM4EMEN1 | |
| SCHEMBL6482125 | 0.80 | HTR6 (0.56) | HTR6PTGS1PTGS2HSD17B10ALOX5 | |
| SCHEMBL31716058 | 0.78 | CCNB2 (0.43) | HTR6NR1H2HSD17B10CCNB2CDK1 | |
| SCHEMBL6483062 | 0.76 | CHRM2 (0.49) | HTR6NR1H2HSD17B10CCNB2CDK1 | |
| SCHEMBL31716619 | 0.75 | TSHR (0.38) | HTR6NR1H2HSD17B10TSHRALDH1A1 | |
| SCHEMBL31716314 | 0.75 | KDM4E (0.41) | NR1H2HSD17B10TSHRALDH1A1KDM4E | |
| SCHEMBL28808534 | 0.72 | NR1H2 (0.40) | HTR6NR1H2CCNB2CDK1CCNB1 | |
| SCHEMBL28808533 | 0.72 | GABRG2 (0.43) | HTR6NR1H2CCNB2CDK1CCNB1 | |
| SCHEMBL10152246 | 0.71 | HSD17B10 (0.76) | HTR6HSD17B10KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1248777-A2 | TRICYCLIC COMPOUNDS WITH ANTIVIRAL ACTIVITY | WARNER-LAMBERT COMPANY (US) | 2002-10-16 | — | — | EP | disclosed |
| WO-2001051479-A2 | TRICYCLIC COMPOUNDS WITH ANTIVIRAL ACTIVITY | WARNER-LAMBERT COMPANY (US) | 2001-07-19 | — | — | WO | disclosed |