SCHEMBL7547853

SCHEMBL7547853

C[C@@H]1CCN(OCc2cccnc2)C1

nearest known ligand 0.53

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
CHRM2 P08172 4/20 0.52
CHRM1 P11229 4/20 0.52
CHRM3 P20309 4/20 0.52
HRH3 Q9Y5N1 1/20 0.45
CHRNB2 P17787 4/20 0.44
CHRNA4 P43681 4/20 0.44
OGA O60502 2/20 0.44
KDM4E B2RXH2 2/20 0.42
ALDH1A1 P00352 1/20 0.42
CHRNA7 P36544 1/20 0.42
KMT2A Q03164 1/20 0.41
HRH4 Q9H3N8 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7546085 0.77 CHRNB2 (0.57) CHRM2CHRM1CHRM3HRH3CHRNB2
SCHEMBL14197746 0.75 CHRNB2 (0.59) HRH3CHRNB2CHRNA4KDM4EALDH1A1
SCHEMBL12449679 0.73 CHRNB2 (0.65) CHRM2CHRM1CHRM3HRH3CHRNB2
SCHEMBL13212690 0.73 CHRNB2 (0.65) CHRM2CHRM1CHRM3HRH3CHRNB2
SCHEMBL12250 0.73 CHRNB2 (0.65) CHRM2CHRM1CHRM3HRH3CHRNB2
SCHEMBL30574692 0.72 CHRNB2 (0.68) HRH3CHRNB2CHRNA4OGAKDM4E
SCHEMBL12424619 0.72 CHRNB2 (0.68) HRH3CHRNB2CHRNA4OGAKDM4E
SCHEMBL15014505 0.70 CHRNB2 (0.69) HRH3CHRNB2CHRNA4KDM4EALDH1A1
SCHEMBL7593846 0.69 CHRM2 (0.85) CHRM2CHRM1CHRM3HRH3CHRNB2
SCHEMBL7553856 0.69 CHRM2 (0.71) CHRM2CHRM1CHRM3HRH3CHRNB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1212301-A1 ARYLALKYLOXYALKYLAMINES AND ARYLALKYLTHIOALKYLAMINES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS INHIBITORS OF NICOTINIC CHOLINERGIC RECEPTORS Targacept, Inc. (US) 2002-06-12 EP disclosed
WO-2001016107-A1 ARYLALKYLOXYALKYLAMINES AND ARYLALKYLTHIOALKYLAMINES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS INHIBITORS OF NICOTINIC CHOLINERGIC RECEPTORS TARGACEPT, INC. (US) 2001-03-08 WO disclosed