SCHEMBL7546085

SCHEMBL7546085

c1cncc(CON2CCCC2)c1

nearest known ligand 0.57

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 4/20 0.57
CHRNA4 P43681 4/20 0.57
CHRM2 P08172 3/20 0.49
CHRM1 P11229 3/20 0.49
CHRM3 P20309 3/20 0.49
LTA4H P09960 1/20 0.46
CYP1A2 P05177 1/20 0.43
CYP2D6 P10635 1/20 0.43
HRH3 Q9Y5N1 1/20 0.42
CHRNA7 P36544 2/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7547853 0.77 CHRM2 (0.52) CHRNB2CHRNA4CHRM2CHRM1CHRM3
SCHEMBL8310756 0.77 CYP1A2 (0.50) LTA4HCYP1A2HRH3
Hydrochloric Acid SCHEMBL2978407 0.76 LMNA (0.46) LTA4HHRH3
SCHEMBL447549 0.76 SIGMAR1 (0.47) LTA4HHRH3
Bromide SCHEMBL28805308 0.74 SIGMAR1 (0.46) LTA4HHRH3
SCHEMBL15094370 0.74 TSHR (0.46) LTA4HHRH3
SCHEMBL493020 0.73 CYP1A2 (0.56) CHRNB2CHRNA4CHRM2CHRM1CHRM3
N-(3-Pyridylmethyl)Pyrrolidine SCHEMBL30341021 0.73 CHRNB2 (1.00) CHRNB2CHRNA4LTA4H
N-(3-Pyridylmethyl)Pyrrolidine SCHEMBL1538320 0.73 CHRNB2 (1.00) CHRNB2CHRNA4LTA4H
SCHEMBL5792708 0.72 OPRK1 (0.56) CHRNB2CHRNA4CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1212301-A1 ARYLALKYLOXYALKYLAMINES AND ARYLALKYLTHIOALKYLAMINES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS INHIBITORS OF NICOTINIC CHOLINERGIC RECEPTORS Targacept, Inc. (US) 2002-06-12 EP disclosed
WO-2001016107-A1 ARYLALKYLOXYALKYLAMINES AND ARYLALKYLTHIOALKYLAMINES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS INHIBITORS OF NICOTINIC CHOLINERGIC RECEPTORS TARGACEPT, INC. (US) 2001-03-08 WO disclosed