Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 1/20 | 0.34 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.33 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 2/20 | 0.30 |
| ▸ | MAPT | P10636 | 2/20 | 0.30 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.30 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | CDK1 | P06493 | 1/20 | 0.30 |
| ▸ | KDR | P35968 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | GBA1 | P04062 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | CRHBP | P24387 | 1/20 | 0.30 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7544855 | 0.85 | CCR4 (0.35) | — | |
| SCHEMBL7541273 | 0.81 | NPSR1 (0.42) | MAPTKDM4ETSHRHTTHSD17B10 | |
| SCHEMBL7547389 | 0.77 | KDM4E (0.41) | MAPTKDM4ETSHRHSD17B10NPC1 | |
| SCHEMBL7542145 | 0.75 | PARP10 (0.39) | MAPTKDM4ETSHR | |
| SCHEMBL7541370 | 0.75 | ALDH1A1 (0.44) | MAPTKDM4EHTTHSD17B10NPC1 | |
| SCHEMBL12409948 | 0.71 | GRM5 (0.36) | GRM5MAPTKDM4ETSHRHTT | |
| SCHEMBL7542788 | 0.70 | SLC13A5 (0.35) | CDK2MAPTCCNA2CCNA1KDM4E | |
| SCHEMBL10304917 | 0.68 | PIK3CA (0.37) | GRM5CDK2CCNA2CCNA1L3MBTL1 | |
| SCHEMBL7543209 | 0.68 | ALDH1A1 (0.43) | MAPTHTTHSD17B10NPC1TP53 | |
| SCHEMBL16043730 | 0.65 | HPGD (0.39) | GRM5CDK2MAPTCDK1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0889038-B1 | Process for the preparation of alkoxy-or aryloxypyrazine derivatives | LONZA AG (CH) | 2002-05-29 | — | — | EP | claimed |
| US-20010012894-A1 | Process for preparing alkoxypyrazine derivatives | FUCHS RUDOLF (CH) | 2001-08-09 | — | — | US | claimed |
| US-6066736-A | Process for preparing alkoxypyrazine derivatives | LONZA AG (CH) | 2000-05-23 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010012894-A1 | Process for preparing alkoxypyrazine derivatives | CYP3A5, GMDS, CYP3A43 | DGAT1 3731/4885PDCD1LG2 4817/4885CD274 4869/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.