Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | GMNN | O75496 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7541370 | 0.89 | ALDH1A1 (0.44) | NPSR1KMT2AALDH1A1MAPTHTT | |
| SCHEMBL7541379 | 0.85 | NPSR1 (0.47) | NPSR1S1PR4ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL7547389 | 0.83 | KDM4E (0.41) | KMT2AALDH1A1MAPTSMN1; SMN2KDM4E | |
| SCHEMBL7542145 | 0.82 | PARP10 (0.39) | NPSR1ALDH1A1MAPTSMN1; SMN2KDM4E | |
| SCHEMBL7543209 | 0.81 | ALDH1A1 (0.43) | NPSR1ALDH1A1MAPTHTTL3MBTL1 | |
| SCHEMBL7547883 | 0.81 | DGAT1 (0.34) | MAPTHTTL3MBTL1KDM4ENPC1 | |
| SCHEMBL5767143 | 0.79 | NPSR1 (0.58) | NPSR1S1PR4KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL7542788 | 0.76 | SLC13A5 (0.35) | ALDH1A1MAPTSMN1; SMN2KDM4ENPC1 | |
| SCHEMBL24992979 | 0.75 | NPC1 (0.47) | ALDH1A1SMN1; SMN2L3MBTL1KDM4ENPC1 | |
| SCHEMBL5767151 | 0.75 | NPSR1 (0.47) | NPSR1S1PR4KMT2AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0889038-B1 | Process for the preparation of alkoxy-or aryloxypyrazine derivatives | LONZA AG (CH) | 2002-05-29 | — | — | EP | claimed |
| US-20010012894-A1 | Process for preparing alkoxypyrazine derivatives | FUCHS RUDOLF (CH) | 2001-08-09 | — | — | US | claimed |
| US-6066736-A | Process for preparing alkoxypyrazine derivatives | LONZA AG (CH) | 2000-05-23 | — | — | US | claimed |
| US-6291674-B2 | REACTING GLYOXAL DERIVATIVE AND AMINOIMIDATE DERIVATIVE TO FORM 3-ALKOXY/ARYLOXY-5-(ALKYL/ARYL)PYRAZINE-2-CARBOXAMIDE; REACTING WITH ALKALI METAL HYPOHALITE TO FORM 3-ALKOXY/ARYLOXY-5-(ALKYL/ARYL)PYRAZINE-2-AMINE | LONZA AG (CH) | 2001-09-18 | — | — | US | disclosed |
| US-20010012894-A1 | Process for preparing alkoxypyrazine derivatives | FUCHS RUDOLF (CH) | 2001-08-09 | — | — | US | disclosed |
| US-6235905-B1 | REACTING A GLYOXAL DERIVATIVE WITH A AMINOACETIMIDATE | LONZA AG (CH) | 2001-05-22 | — | — | US | disclosed |
| US-6066736-A | Process for preparing alkoxypyrazine derivatives | LONZA AG (CH) | 2000-05-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010012894-A1 | Process for preparing alkoxypyrazine derivatives | CYP3A5, GMDS, CYP3A43 | NPSR1 2997/4885S1PR4 3684/4885KMT2A 3024/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.