Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 4/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.36 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL31219767 | 0.98 | KDM1A (0.44) | KDM1ADRD2DRD3TLR9TLR8 | |
| SCHEMBL19097411 | 0.81 | ESR2 (0.41) | KDM1ATLR9TLR8TLR7 | |
| SCHEMBL8193235 | 0.81 | ESR2 (0.41) | KDM1ATLR9TLR8TLR7 | |
| SCHEMBL6042043 | 0.81 | ESR2 (0.41) | KDM1ATLR9TLR8TLR7 | |
| SCHEMBL4659995 | 0.79 | HTR3A (0.58) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL6042034 | 0.79 | TLR9 (0.44) | KDM1ATLR9TLR8TLR7 | |
| SCHEMBL13818151 | 0.79 | GRK2 (0.47) | KDM1ATLR9TLR8TLR7SLC6A2 | |
| SCHEMBL6042307 | 0.79 | GRK2 (0.47) | KDM1ATLR9TLR8TLR7SLC6A2 | |
| SCHEMBL6041893 | 0.79 | FPR1 (0.44) | KDM1ATLR9TLR8TLR7SLC6A4 | |
| Hydrochloric Acid SCHEMBL4601092 | 0.79 | GRK2 (0.41) | KDM1ATLR9TLR8TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863875-A1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | F. HOFFMANN-LA ROCHE AG (CH) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997009311-A1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | F. HOFFMANN-LA ROCHE AG (CH) | 1997-03-13 | — | — | WO | disclosed |