Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 5/20 | 0.57 |
| ▸ | HTR6 | P50406 | 2/20 | 0.46 |
| ▸ | GSK3B | P49841 | 6/20 | 0.41 |
| ▸ | FLT1 | P17948 | 3/20 | 0.40 |
| ▸ | FLT4 | P35916 | 3/20 | 0.40 |
| ▸ | PRKCA | P17252 | 5/20 | 0.40 |
| ▸ | PRKACB | P22694 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | PRKACA | P17612 | 1/20 | 0.39 |
| ▸ | PRKACG | P22612 | 1/20 | 0.39 |
| ▸ | HTR1D | P28221 | 1/20 | 0.38 |
| ▸ | PRKCB | P05771 | 3/20 | 0.38 |
| ▸ | PRKCG | P05129 | 2/20 | 0.38 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7548728 | 0.91 | KDR (0.52) | KDRHTR6GSK3BFLT1FLT4 | |
| SCHEMBL7976532 | 0.89 | KDR (0.51) | KDRHTR6GSK3BFLT1FLT4 | |
| SCHEMBL7549825 | 0.89 | KDR (0.51) | KDRHTR6GSK3BPRKACBPRKACA | |
| SCHEMBL7547677 | 0.87 | KDR (0.49) | KDRHTR6GSK3BPIM1HTR1D | |
| SCHEMBL7508695 | 0.87 | KDR (0.74) | KDRHTR6GSK3BFLT1FLT4 | |
| SCHEMBL7557087 | 0.84 | KDR (0.77) | KDRGSK3BFLT1FLT4PRKCA | |
| SCHEMBL7547227 | 0.82 | KDR (0.60) | KDRGSK3BFLT1FLT4PRKCA | |
| SCHEMBL7556924 | 0.81 | KDR (0.59) | KDRGSK3BFLT1FLT4PRKCA | |
| SCHEMBL7986720 | 0.81 | KDR (0.59) | KDRHTR6FLT1FLT4PRKACB | |
| SCHEMBL7550081 | 0.80 | KDR (0.56) | KDRGSK3BFLT1FLT4PRKCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1147107-A4 | NOVEL ANGIOGENESIS INHIBITORS | MERCK & CO INC (US) | 2002-05-22 | — | — | EP | claimed |
| EP-1147107-A1 | NOVEL ANGIOGENESIS INHIBITORS | Merck & Co., Inc. (US) | 2001-10-24 | — | — | EP | claimed |
| WO-2000043393-A1 | NOVEL ANGIOGENESIS INHIBITORS | MERCK & CO., INC. (US) | 2000-07-27 | — | — | WO | claimed |
| EP-1147107-A4 | NOVEL ANGIOGENESIS INHIBITORS | MERCK & CO INC (US) | 2002-05-22 | — | — | EP | disclosed |
| EP-1147107-A1 | NOVEL ANGIOGENESIS INHIBITORS | Merck & Co., Inc. (US) | 2001-10-24 | — | — | EP | disclosed |
| US-6265403-B1 | TYROSINE INHIBITORS | MERCK & CO., INC. | 2001-07-24 | — | — | US | disclosed |
| WO-2000043393-A1 | NOVEL ANGIOGENESIS INHIBITORS | MERCK & CO., INC. (US) | 2000-07-27 | — | — | WO | disclosed |