Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 4/20 | 0.59 |
| ▸ | FLT1 | P17948 | 2/20 | 0.59 |
| ▸ | FLT4 | P35916 | 2/20 | 0.59 |
| ▸ | PRKACA | P17612 | 1/20 | 0.38 |
| ▸ | PRKACG | P22612 | 1/20 | 0.38 |
| ▸ | PRKACB | P22694 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | NR1D1 | P20393 | 1/20 | 0.32 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.32 |
| ▸ | BRD7 | Q9NPI1 | 1/20 | 0.32 |
| ▸ | ASH1L | Q9NR48 | 1/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.31 |
| ▸ | HTR1A | P08908 | 2/20 | 0.31 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.31 |
| ▸ | DRD1 | P21728 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7551380 | 0.91 | KDR (0.54) | KDRFLT1FLT4PRKACAPRKACG | |
| SCHEMBL7549028 | 0.89 | KDR (0.52) | KDRFLT1FLT4PRKACAPRKACG | |
| SCHEMBL7555413 | 0.89 | KDR (0.52) | KDRFLT1FLT4PRKACAPRKACG | |
| SCHEMBL7547036 | 0.88 | FLT1 (0.51) | KDRFLT1FLT4DYRK1AGRIN2B | |
| SCHEMBL7976803 | 0.88 | KDR (0.75) | KDRFLT1FLT4PRKACAPRKACG | |
| SCHEMBL7550357 | 0.85 | KDR (0.78) | KDRFLT1FLT4PRKACAPRKACG | |
| SCHEMBL7551901 | 0.83 | KDR (0.42) | KDRFLT1FLT4HTR6GRIN2B | |
| SCHEMBL7548397 | 0.81 | KDR (0.57) | KDRFLT1FLT4PRKACAPRKACG | |
| SCHEMBL7986816 | 0.81 | KDR (0.58) | KDRFLT1FLT4PRKACAPRKACG | |
| SCHEMBL7987886 | 0.79 | KDR (0.63) | KDRFLT1FLT4PRKACAPRKACG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6265403-B1 | TYROSINE INHIBITORS | MERCK & CO., INC. | 2001-07-24 | — | — | US | disclosed |