Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 3/20 | 0.51 |
| ▸ | PRKCB | P05771 | 3/20 | 0.41 |
| ▸ | PRKCA | P17252 | 3/20 | 0.41 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.40 |
| ▸ | HTR6 | P50406 | 4/20 | 0.39 |
| ▸ | GSK3B | P49841 | 5/20 | 0.37 |
| ▸ | PRKCG | P05129 | 2/20 | 0.37 |
| ▸ | HTR1D | P28221 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.37 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | FLT1 | P17948 | 1/20 | 0.35 |
| ▸ | FLT4 | P35916 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7548728 | 0.90 | KDR (0.52) | KDRPRKCBPRKCAPRKCEHTR6 | |
| SCHEMBL7548397 | 0.89 | KDR (0.57) | KDRPRKCBPRKCAPRKCEHTR6 | |
| SCHEMBL7547677 | 0.87 | KDR (0.49) | KDRGRIN2BHTR6GSK3BHTR1D | |
| SCHEMBL7550695 | 0.85 | KDR (0.69) | KDRPRKCBPRKCAPRKCEGSK3B | |
| SCHEMBL7990794 | 0.84 | KDR (0.52) | KDRPRKCBPRKCAPRKCEGRIN2B | |
| SCHEMBL7990841 | 0.84 | KDR (0.54) | KDRHTR6GSK3BFLT1FLT4 | |
| SCHEMBL7976106 | 0.83 | KDR (0.58) | KDRPRKCBPRKCAPRKCEGRIN2B | |
| SCHEMBL7987952 | 0.83 | KDR (0.58) | KDRPRKCBPRKCAPRKCEGRIN2B | |
| SCHEMBL7551303 | 0.83 | KDR (0.52) | KDRGRIN2BGSK3BGRIN1FLT1 | |
| SCHEMBL7555413 | 0.83 | KDR (0.52) | KDRGRIN2BHTR6GRIN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6265403-B1 | TYROSINE INHIBITORS | MERCK & CO., INC. | 2001-07-24 | — | — | US | disclosed |