SCHEMBL7548474

SCHEMBL7548474

CC(C1CCCNC1)n1cc(-c2cncc(-c3ccccc3)c2)c2ccc(Cl)cc21

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK7 P50613 4/20 0.42
CCNH P51946 4/20 0.42
MNAT1 P51948 4/20 0.42
CCNT1 O60563 3/20 0.42
CDK9 P50750 3/20 0.42
CDK2 P24941 2/20 0.42
CCNE1 P24864 1/20 0.42
PRKCZ Q05513 4/20 0.35
PRKD2 Q9BZL6 3/20 0.35
JAK1 P23458 1/20 0.33
JAK3 P52333 1/20 0.33
SLC6A2 P23975 4/20 0.33
SLC6A4 P31645 4/20 0.33
SLC6A3 Q01959 4/20 0.33
CHEK1 O14757 1/20 0.33
CCNA2 P20248 1/20 0.33
CCNA1 P78396 1/20 0.33
CYP2D6 P10635 1/20 0.32
HTR2A P28223 1/20 0.32
KCNH2 Q12809 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7987644 0.94 CCNT1 (0.40) CDK7CCNHMNAT1CCNT1CDK9
SCHEMBL7986848 0.94 CCNT1 (0.38) CDK7CCNHMNAT1CCNT1CDK9
SCHEMBL7987305 0.93 CCNT1 (0.42) CDK7CCNHMNAT1CCNT1CDK9
SCHEMBL7513288 0.90 CDK7 (0.47) CDK7CCNHMNAT1CCNT1CDK9
SCHEMBL7991016 0.90 CCNT1 (0.37) CDK7CCNHMNAT1CCNT1CDK9
SCHEMBL7990984 0.89 CCNT1 (0.36) CDK7CCNHMNAT1CCNT1CDK9
SCHEMBL7991127 0.88 CDK7 (0.46) CDK7CCNHMNAT1CCNT1CDK9
SCHEMBL7986901 0.88 KDR (0.41) CDK7CCNHMNAT1CCNT1CDK9
SCHEMBL7986838 0.87 CCNT1 (0.40) CDK7CCNHMNAT1CCNT1CDK9
SCHEMBL7503926 0.86 CCNT1 (0.38) CDK7CCNHMNAT1CCNT1CDK9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1147107-A4 NOVEL ANGIOGENESIS INHIBITORS MERCK & CO INC (US) 2002-05-22 EP claimed
EP-1147107-A1 NOVEL ANGIOGENESIS INHIBITORS Merck & Co., Inc. (US) 2001-10-24 EP claimed
WO-2000043393-A1 NOVEL ANGIOGENESIS INHIBITORS MERCK & CO., INC. (US) 2000-07-27 WO claimed
US-6265403-B1 TYROSINE INHIBITORS MERCK & CO., INC. 2001-07-24 US disclosed