Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 8/20 | 0.41 |
| ▸ | FLT1 | P17948 | 4/20 | 0.41 |
| ▸ | FLT4 | P35916 | 4/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 4/20 | 0.36 |
| ▸ | CDK2 | P24941 | 3/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.36 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.36 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.35 |
| ▸ | CDK7 | P50613 | 1/20 | 0.35 |
| ▸ | CDK9 | P50750 | 1/20 | 0.35 |
| ▸ | CCNH | P51946 | 1/20 | 0.35 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.35 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.34 |
| ▸ | TDP2 | O95551 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.32 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.32 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7548212 | 0.93 | KDR (0.39) | KDRFLT1FLT4CHEK1CDK2 | |
| SCHEMBL7987644 | 0.89 | CCNT1 (0.40) | CHEK1CDK2CCNT1CCNE1CDK7 | |
| SCHEMBL7510914 | 0.89 | KDR (0.51) | KDRFLT1FLT4CHEK1CDK2 | |
| SCHEMBL7548474 | 0.88 | CDK7 (0.42) | CHEK1CDK2CCNA2CCNA1CCNT1 | |
| SCHEMBL7986848 | 0.87 | CCNT1 (0.38) | CHEK1CDK2CCNT1CCNE1CDK7 | |
| SCHEMBL7991016 | 0.85 | CCNT1 (0.37) | CHEK1CDK2CCNT1CCNE1CDK7 | |
| SCHEMBL7993811 | 0.84 | KDR (0.39) | KDRFLT1FLT4CHEK1CDK2 | |
| SCHEMBL7993904 | 0.83 | KDR (0.38) | KDRFLT1FLT4CHEK1CDK2 | |
| SCHEMBL7976003 | 0.83 | PRKCZ (0.40) | KDRFLT1FLT4CHEK1CDK2 | |
| SCHEMBL7990984 | 0.83 | CCNT1 (0.36) | CHEK1CDK2CCNT1CCNE1CDK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6265403-B1 | TYROSINE INHIBITORS | MERCK & CO., INC. | 2001-07-24 | — | — | US | disclosed |