Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK7 | P50613 | 4/20 | 0.47 |
| ▸ | CCNH | P51946 | 4/20 | 0.47 |
| ▸ | MNAT1 | P51948 | 4/20 | 0.47 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.47 |
| ▸ | CDK9 | P50750 | 3/20 | 0.47 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | PRKCZ | Q05513 | 4/20 | 0.38 |
| ▸ | PRKD2 | Q9BZL6 | 3/20 | 0.38 |
| ▸ | KDR | P35968 | 5/20 | 0.36 |
| ▸ | FLT1 | P17948 | 3/20 | 0.36 |
| ▸ | FLT4 | P35916 | 3/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7986667 | 0.91 | CDK7 (0.44) | CDK7CCNHMNAT1CCNT1CDK9 | |
| SCHEMBL7991127 | 0.91 | CDK7 (0.46) | CDK7CCNHMNAT1CCNT1CDK9 | |
| SCHEMBL7548474 | 0.90 | CDK7 (0.42) | CDK7CCNHMNAT1CCNT1CDK9 | |
| SCHEMBL7987305 | 0.90 | CCNT1 (0.42) | CDK7CCNHMNAT1CCNT1CDK9 | |
| SCHEMBL7976272 | 0.89 | CCNT1 (0.41) | CDK7CCNHMNAT1CCNT1CDK9 | |
| SCHEMBL7510914 | 0.89 | KDR (0.51) | CDK7CCNHMNAT1CCNT1CDK9 | |
| SCHEMBL7505916 | 0.88 | CCNT1 (0.38) | CDK7CCNHMNAT1CCNT1CDK9 | |
| SCHEMBL7990448 | 0.88 | CYP11B1 (0.40) | CDK7CCNHMNAT1CCNT1CDK9 | |
| SCHEMBL7977291 | 0.86 | EGFR (0.38) | CDK7CCNHMNAT1CCNT1CDK9 | |
| SCHEMBL7990707 | 0.86 | CDK9 (0.44) | CDK7CCNHMNAT1CCNT1CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1147107-A4 | NOVEL ANGIOGENESIS INHIBITORS | MERCK & CO INC (US) | 2002-05-22 | — | — | EP | claimed |
| EP-1147107-A1 | NOVEL ANGIOGENESIS INHIBITORS | Merck & Co., Inc. (US) | 2001-10-24 | — | — | EP | claimed |
| WO-2000043393-A1 | NOVEL ANGIOGENESIS INHIBITORS | MERCK & CO., INC. (US) | 2000-07-27 | — | — | WO | claimed |
| EP-1147107-A4 | NOVEL ANGIOGENESIS INHIBITORS | MERCK & CO INC (US) | 2002-05-22 | — | — | EP | disclosed |
| EP-1147107-A1 | NOVEL ANGIOGENESIS INHIBITORS | Merck & Co., Inc. (US) | 2001-10-24 | — | — | EP | disclosed |
| US-6265403-B1 | TYROSINE INHIBITORS | MERCK & CO., INC. | 2001-07-24 | — | — | US | disclosed |
| WO-2000043393-A1 | NOVEL ANGIOGENESIS INHIBITORS | MERCK & CO., INC. (US) | 2000-07-27 | — | — | WO | disclosed |