Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 11/20 | 0.48 |
| ▸ | FAAH | O00519 | 1/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | GBA1 | P04062 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7548567 | 1.00 | GPR119 (0.48) | GPR119FAAHCCNA2CDK2KDM4E | |
| SCHEMBL5764083 | 0.91 | GPR119 (0.57) | GPR119CCNA2CDK2KDM4EPKM | |
| SCHEMBL5764087 | 0.91 | GPR119 (0.57) | GPR119CCNA2CDK2KDM4EPKM | |
| SCHEMBL5762340 | 0.90 | GPR119 (0.58) | GPR119FAAHCCNA2CDK2KDM4E | |
| SCHEMBL4237414 | 0.78 | KDM4E (0.56) | GPR119KDM4EPKM | |
| SCHEMBL4237418 | 0.78 | KDM4E (0.56) | GPR119KDM4EPKM | |
| SCHEMBL12892148 | 0.77 | GPR119 (0.51) | GPR119FAAHCCNA2CDK2KDM4E | |
| SCHEMBL7732370 | 0.77 | KDM4E (0.67) | GPR119FAAHKDM4EPKM | |
| SCHEMBL31663064 | 0.75 | GPR119 (0.57) | GPR119CCNA2CDK2KDM4EPKM | |
| SCHEMBL6979528 | 0.74 | KDM4E (0.76) | GPR119CCNA2CDK2KDM4EPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1192133-A1 | N-CYCLOPENTYL MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | Merck & Co., Inc. (US) | 2002-04-03 | — | — | EP | disclosed |
| WO-2000076972-A1 | N-CYCLOPENTYL MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | MERCK & CO., INC. (US) | 2000-12-21 | — | — | WO | disclosed |