Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM8 | O00222 | 6/20 | 0.56 |
| ▸ | GRM4 | Q14833 | 6/20 | 0.56 |
| ▸ | GSR | P00390 | 1/20 | 0.54 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.51 |
| ▸ | GRM6 | O15303 | 4/20 | 0.45 |
| ▸ | GRM7 | Q14831 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL7542135 | 1.00 | GRM8 (0.56) | GRM8GRM4GSRGPR35GRM6 | |
| Lysine SCHEMBL28251933 | 0.89 | GSR (0.54) | GRM8GRM4GSRGPR35GRM6 | |
| Lysine SCHEMBL2678982 | 0.88 | GSR (0.53) | GRM8GRM4GSRGRM6GRM7 | |
| Lysine SCHEMBL2462408 | 0.87 | GPR35 (0.56) | GRM8GRM4GSRGPR35GRM6 | |
| Trinitrophenol SCHEMBL3985940 | 0.85 | GRM8 (0.57) | GRM8GRM4GSRGPR35GRM6 | |
| Lysine SCHEMBL20303615 | 0.85 | GSR (0.53) | GRM8GRM4GSR | |
| Trinitrophenol SCHEMBL3985938 | 0.85 | GRM8 (0.57) | GRM8GRM4GSRGPR35GRM6 | |
| Lysine SCHEMBL10755723 | 0.83 | GRM4 (0.52) | GRM8GRM4GSRGPR35GRM6 | |
| Dinitrophenylene SCHEMBL28977791 | 0.82 | KMO (0.58) | GRM8GRM4GSRGRM6 | |
| Lysine SCHEMBL12478274 | 0.82 | GSR (0.46) | GRM8GRM4GSRGRM6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0876602-B1 | DETERMINATION OF AN ANALYTE IN LIQUID MEDIUM | YISSUM RES DEV CO (IL) | 2002-05-29 | — | — | EP | disclosed |
| US-6214205-B1 | ELECTROLYSIS | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) | 2001-04-10 | — | — | US | disclosed |
| EP-0876602-A1 | DETERMINATION OF AN ANALYTE IN LIQUID MEDIUM | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) | 1998-11-11 | — | — | EP | disclosed |
| WO-1997027474-A1 | DETERMINATION OF AN ANALYTE IN A LIQUID MEDIUM | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) | 1997-07-31 | — | — | WO | disclosed |