Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSB | P07858 | 5/20 | 0.52 |
| ▸ | CTSS | P25774 | 5/20 | 0.52 |
| ▸ | CTSL | P07711 | 5/20 | 0.52 |
| ▸ | CTSK | P43235 | 2/20 | 0.52 |
| ▸ | CTSF | Q9UBX1 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CTSV | O60911 | 1/20 | 0.46 |
| ▸ | ECE1 | P42892 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | CTRC | Q99895 | 1/20 | 0.41 |
| ▸ | GPR132 | Q9UNW8 | 5/20 | 0.41 |
| ▸ | CMKLR2 | P46091 | 1/20 | 0.41 |
| ▸ | CMKLR1 | Q99788 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6062317 | 1.00 | CTSB (0.52) | CTSBCTSSCTSLCTSKCTSF | |
| SCHEMBL6061905 | 0.90 | CTSL (0.62) | CTSBCTSSCTSLCTSKCTSF | |
| SCHEMBL6741441 | 0.86 | CTSL (0.58) | CTSBCTSSCTSLCTSKCTSF | |
| SCHEMBL6740951 | 0.84 | CTSL (0.62) | CTSBCTSSCTSLCTSKLMNA | |
| SCHEMBL6740948 | 0.84 | CTSL (0.62) | CTSBCTSSCTSLCTSKLMNA | |
| SCHEMBL6742310 | 0.84 | CTSL (0.58) | CTSBCTSSCTSLCTSKCTSF | |
| SCHEMBL6737785 | 0.84 | CTSL (0.58) | CTSBCTSSCTSLCTSKCTSF | |
| SCHEMBL6062078 | 0.84 | CTSL (0.58) | CTSBCTSSCTSLCTSKCTSF | |
| SCHEMBL6744072 | 0.83 | CTSL (0.52) | CTSBCTSSCTSLCTSKCTSF | |
| SCHEMBL6061828 | 0.83 | CTSB (0.43) | CTSBCTSSCTSLCTSKCTSF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1212302-A1 | COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS AS CATHEPSIN S INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2002-06-12 | — | — | EP | disclosed |
| WO-2001019796-A1 | COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS AS CATHEPSIN S INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2001-03-22 | — | — | WO | disclosed |