Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.38 |
| ▸ | HTR1B | P28222 | 2/20 | 0.37 |
| ▸ | HTR1D | P28221 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20255422 | 0.82 | CHRNB2 (0.37) | CHRNB2CHRNA4HTR1BHTR1DLMNA | |
| SCHEMBL21241056 | 0.79 | APP (0.41) | GAAPLA2G7MEN1LMNAKMT2A | |
| SCHEMBL487644 | 0.77 | TSHR (0.39) | GAAPLA2G7MEN1LMNAKMT2A | |
| SCHEMBL12402009 | 0.77 | AGXT (0.47) | HTR1BHTR1DTMEM97SIGMAR1 | |
| SCHEMBL12140714 | 0.77 | GAA (0.58) | GAAMEN1LMNAKMT2ATSHR | |
| SCHEMBL7551451 | 0.77 | CHRNB2 (0.57) | CHRNB2CHRNA4MEN1KMT2AL3MBTL1 | |
| SCHEMBL21169049 | 0.77 | MEN1 (0.40) | GAAPLA2G7MEN1LMNAKMT2A | |
| SCHEMBL7548586 | 0.74 | MEN1 (0.38) | GAAPLA2G7MEN1LMNAKMT2A | |
| SCHEMBL7841404 | 0.74 | PDE1B (0.39) | GAAPLA2G7MEN1LMNAKMT2A | |
| SCHEMBL20038389 | 0.74 | GAA (0.51) | GAAPLA2G7MEN1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7998706-B2 | Pyrimidine nucleobases | APPLIED BIOSYSTEMS, LLC (US) | 2011-08-16 | — | — | US | disclosed |
| EP-1212301-A1 | ARYLALKYLOXYALKYLAMINES AND ARYLALKYLTHIOALKYLAMINES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS INHIBITORS OF NICOTINIC CHOLINERGIC RECEPTORS | Targacept, Inc. (US) | 2002-06-12 | — | — | EP | disclosed |
| WO-2001016107-A1 | ARYLALKYLOXYALKYLAMINES AND ARYLALKYLTHIOALKYLAMINES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS INHIBITORS OF NICOTINIC CHOLINERGIC RECEPTORS | TARGACEPT, INC. (US) | 2001-03-08 | — | — | WO | disclosed |