Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.34 |
| ▸ | TACR1 | P25103 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2609181 | 0.83 | LMNA (0.41) | MEN1LMNAKMT2AGAAPLA2G7 | |
| SCHEMBL7547886 | 0.78 | CHRNB2 (0.46) | — | |
| SCHEMBL7545392 | 0.78 | CHRNB2 (0.46) | — | |
| SCHEMBL487644 | 0.74 | TSHR (0.39) | MEN1LMNAKMT2AGAAPLA2G7 | |
| SCHEMBL7548902 | 0.74 | CHRNB2 (0.41) | MEN1LMNAKMT2AGAAPLA2G7 | |
| SCHEMBL25666197 | 0.73 | TAAR1 (0.57) | MEN1KMT2ATACR1 | |
| SCHEMBL21444695 | 0.73 | TAAR1 (0.57) | MEN1KMT2ATACR1 | |
| SCHEMBL14348154 | 0.73 | MEN1 (0.43) | MEN1LMNAKMT2AGAAPLA2G7 | |
| SCHEMBL7841404 | 0.71 | PDE1B (0.39) | MEN1LMNAKMT2AGAAPLA2G7 | |
| SCHEMBL7548604 | 0.71 | NPC1 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1212301-A1 | ARYLALKYLOXYALKYLAMINES AND ARYLALKYLTHIOALKYLAMINES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS INHIBITORS OF NICOTINIC CHOLINERGIC RECEPTORS | Targacept, Inc. (US) | 2002-06-12 | — | — | EP | disclosed |
| WO-2001016107-A1 | ARYLALKYLOXYALKYLAMINES AND ARYLALKYLTHIOALKYLAMINES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS INHIBITORS OF NICOTINIC CHOLINERGIC RECEPTORS | TARGACEPT, INC. (US) | 2001-03-08 | — | — | WO | disclosed |