Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | FABP4 | P15090 | 1/20 | 0.44 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.44 |
| ▸ | BCL2 | P10415 | 3/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.42 |
| ▸ | DPP4 | P27487 | 3/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7546939 | 0.92 | MEN1 (0.60) | MEN1KMT2AALDH1A1SMN1; SMN2FABP4 | |
| SCHEMBL6309562 | 0.89 | MEN1 (0.51) | MEN1KMT2AALDH1A1SMN1; SMN2FABP4 | |
| SCHEMBL6306711 | 0.87 | ALDH1A1 (0.51) | MEN1KMT2AALDH1A1SMN1; SMN2BCL2 | |
| SCHEMBL6308049 | 0.85 | KDM4E (0.57) | MEN1KMT2AALDH1A1SMN1; SMN2DPP4 | |
| SCHEMBL6306748 | 0.84 | MEN1 (0.50) | MEN1KMT2AALDH1A1SMN1; SMN2FABP4 | |
| SCHEMBL6308095 | 0.83 | MEN1 (0.51) | MEN1KMT2AALDH1A1SMN1; SMN2FABP4 | |
| SCHEMBL6309074 | 0.81 | MEN1 (0.48) | MEN1KMT2AALDH1A1SMN1; SMN2FABP4 | |
| SCHEMBL6315697 | 0.81 | MEN1 (0.63) | MEN1KMT2AALDH1A1SMN1; SMN2FABP4 | |
| SCHEMBL6308133 | 0.80 | MEN1 (0.43) | MEN1KMT2AALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL6310577 | 0.80 | ALDH1A1 (0.72) | MEN1KMT2AALDH1A1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1216235-A1 | QUINAZOLINONES | MERCK PATENT GmbH (DE) | 2002-06-26 | — | — | EP | disclosed |
| WO-2001023365-A1 | QUINAZOLINONES | MERCK PATENT GMBH (DE) | 2001-04-05 | — | — | WO | disclosed |