Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 5/20 | 0.50 |
| ▸ | FLT1 | P17948 | 3/20 | 0.45 |
| ▸ | FLT4 | P35916 | 3/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.43 |
| ▸ | HRH2 | P25021 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | SCN7A | Q01118 | 2/20 | 0.39 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.39 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7554511 | 0.95 | KDR (0.51) | KDRFLT1FLT4KDM1AHRH3 | |
| SCHEMBL7504415 | 0.91 | KDR (0.50) | KDRFLT1FLT4KDM1AESR1 | |
| SCHEMBL7549155 | 0.90 | KDR (0.56) | KDRFLT1FLT4CHRNB1CHRNB2 | |
| SCHEMBL7976563 | 0.88 | KDR (0.52) | KDRFLT1FLT4HRH3HRH2 | |
| SCHEMBL7555484 | 0.88 | KDR (0.59) | KDRFLT1FLT4HRH3SCN7A | |
| SCHEMBL7511178 | 0.88 | KDR (0.54) | KDRFLT1FLT4KDM1AHRH3 | |
| SCHEMBL7554609 | 0.86 | KDR (0.52) | KDRFLT1FLT4CHRNB1CHRNB2 | |
| SCHEMBL7556122 | 0.85 | KDR (0.51) | KDRFLT1FLT4HRH3ESR1 | |
| SCHEMBL7555221 | 0.85 | KDR (0.68) | KDRFLT1FLT4FLT3 | |
| SCHEMBL7554276 | 0.84 | KDR (0.52) | KDRFLT1FLT4MCHR1CHRNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6265403-B1 | TYROSINE INHIBITORS | MERCK & CO., INC. | 2001-07-24 | — | — | US | disclosed |