Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | GSTM2 | P28161 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6313461 | 0.94 | F11 (0.41) | TSHRGSTM2USP2CYP1A2CYP3A4 | |
| SCHEMBL6307819 | 0.94 | EGFR (0.42) | TSHRUSP2CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL7554897 | 0.92 | F11 (0.40) | TSHRGSTM2ALDH1A1 | |
| SCHEMBL6308214 | 0.90 | F11 (0.49) | TSHRCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL6305993 | 0.88 | TSHR (0.50) | TSHRUSP2CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL6314138 | 0.84 | F11 (0.45) | POLBRXFP1 | |
| SCHEMBL7551450 | 0.84 | USP2 (0.46) | TSHRUSP2CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL6313234 | 0.82 | F11 (0.52) | TSHRUSP2CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL6308119 | 0.81 | F11 (0.52) | TSHRALDH1A1LMNATP53MEN1 | |
| SCHEMBL6308212 | 0.81 | F11 (0.52) | TSHRUSP2CYP1A2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1216235-A1 | QUINAZOLINONES | MERCK PATENT GmbH (DE) | 2002-06-26 | — | — | EP | disclosed |
| WO-2001023365-A1 | QUINAZOLINONES | MERCK PATENT GMBH (DE) | 2001-04-05 | — | — | WO | disclosed |