Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.50 |
| ▸ | F11 | P03951 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | USP2 | O75604 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.45 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6308119 | 0.94 | F11 (0.52) | TSHRF11ALDH1A1TP53LMNA | |
| SCHEMBL6309689 | 0.93 | F11 (0.48) | TSHRF11POLBRXFP1ALDH1A1 | |
| SCHEMBL6313772 | 0.92 | F11 (0.49) | TSHRF11ALDH1A1LMNAGRIN1 | |
| SCHEMBL6313234 | 0.91 | F11 (0.52) | TSHRF11POLBRXFP1ALDH1A1 | |
| SCHEMBL6309491 | 0.90 | F11 (0.60) | TSHRF11POLBRXFP1ALDH1A1 | |
| SCHEMBL7551450 | 0.89 | USP2 (0.46) | TSHRF11POLBRXFP1ALDH1A1 | |
| SCHEMBL7549261 | 0.88 | TSHR (0.43) | TSHRPOLBRXFP1ALDH1A1USP2 | |
| SCHEMBL6306228 | 0.87 | POLB (0.50) | TSHRF11POLBRXFP1ALDH1A1 | |
| SCHEMBL6308212 | 0.87 | F11 (0.52) | TSHRF11POLBRXFP1ALDH1A1 | |
| SCHEMBL7551638 | 0.86 | F11 (0.47) | TSHRF11ALDH1A1TP53LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6890930-B1 | Quinazolinones | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2005-05-10 | — | — | US | disclosed |
| EP-1216235-A1 | QUINAZOLINONES | MERCK PATENT GmbH (DE) | 2002-06-26 | — | — | EP | disclosed |
| WO-2001023365-A1 | QUINAZOLINONES | MERCK PATENT GMBH (DE) | 2001-04-05 | — | — | WO | disclosed |