Known targets — ChEMBL curated mechanism
KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2
The experimentally established mechanism targets of Dalfampridine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR132 | Q9UNW8 | 8/20 | 0.59 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.55 |
| ▸ | ACE | P12821 | 2/20 | 0.53 |
| ▸ | MME | P08473 | 1/20 | 0.53 |
| ▸ | CPA1 | P15085 | 1/20 | 0.53 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.53 |
| ▸ | CMKLR2 | P46091 | 1/20 | 0.50 |
| ▸ | CMKLR1 | Q99788 | 1/20 | 0.50 |
| ▸ | PPARA | Q07869 | 1/20 | 0.48 |
| ▸ | CTSB | P07858 | 1/20 | 0.47 |
| ▸ | CTSS | P25774 | 1/20 | 0.47 |
| ▸ | CTSK | P43235 | 1/20 | 0.47 |
| ▸ | BCL2 | P10415 | 1/20 | 0.47 |
| ▸ | GPR34 | Q9UPC5 | 2/20 | 0.46 |
| ▸ | YAP1 | P46937 | 1/20 | 0.46 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.46 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31407708 | 0.90 | PTPN1 (0.64) | GPR132PTPN1ACEMMECPA1 | |
| SCHEMBL4650144 | 0.90 | PTPN1 (0.64) | GPR132PTPN1ACEMMECPA1 | |
| SCHEMBL2552297 | 0.90 | PTPN1 (0.64) | GPR132PTPN1ACEMMECPA1 | |
| Dalfampridine SCHEMBL7540843 | 0.85 | ATM (0.58) | GPR132ACEMMECPA1ACE2 | |
| SCHEMBL2353801 | 0.82 | KLK5 (0.59) | GPR132PTPN1ACEMMECPA1 | |
| SCHEMBL20905733 | 0.82 | PTPN1 (0.55) | GPR132PTPN1ACEMMECPA1 | |
| SCHEMBL7709696 | 0.82 | PTPN1 (0.55) | GPR132PTPN1ACEMMECPA1 | |
| SCHEMBL2353808 | 0.82 | KLK5 (0.59) | GPR132PTPN1ACEMMECPA1 | |
| SCHEMBL7366741 | 0.81 | PTPN1 (0.60) | GPR132PTPN1ACEMMECPA1 | |
| Dalfampridine SCHEMBL7439699 | 0.81 | CTSS (0.58) | PTPN1ACEMMEPPARACTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4873253-A | Phenylalanine derivative and proteinase inhibitor | Okamoto, Shosuke (JP) | 1989-10-10 | — | — | US | disclosed |
| EP-0284632-A1 | Phenylalanine derivative and proteinase inhibitor | Okamoto, Shosuke (JP) | 1988-10-05 | — | — | EP | disclosed |