Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA3 | P22001 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.56 |
| ▸ | DRD4 | P21917 | 2/20 | 0.53 |
| ▸ | DRD2 | P14416 | 1/20 | 0.53 |
| ▸ | DRD3 | P35462 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | MAOB | P27338 | 1/20 | 0.53 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.52 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL915402 | 0.93 | KMT2A (0.65) | KCNA3KMT2AL3MBTL1MEN1SIGMAR1 | |
| SCHEMBL555464 | 0.89 | KMT2A (0.64) | KCNA3KMT2AL3MBTL1MEN1SIGMAR1 | |
| SCHEMBL5789230 | 0.88 | KMT2A (0.59) | KCNA3KMT2AL3MBTL1MEN1SIGMAR1 | |
| SCHEMBL3892168 | 0.87 | KMT2A (0.61) | KCNA3KMT2AL3MBTL1MEN1SIGMAR1 | |
| SCHEMBL2241424 | 0.86 | KMT2A (0.63) | KCNA3KMT2AL3MBTL1MEN1SIGMAR1 | |
| SCHEMBL178929 | 0.86 | KMT2A (0.63) | KCNA3KMT2AL3MBTL1MEN1SIGMAR1 | |
| SCHEMBL2241423 | 0.86 | KMT2A (0.63) | KCNA3KMT2AL3MBTL1MEN1SIGMAR1 | |
| SCHEMBL1412221 | 0.84 | KMT2A (0.58) | KCNA3KMT2AL3MBTL1MEN1SIGMAR1 | |
| SCHEMBL1412219 | 0.84 | KMT2A (0.58) | KCNA3KMT2AL3MBTL1MEN1SIGMAR1 | |
| SCHEMBL18845342 | 0.83 | SIGMAR1 (0.57) | KCNA3KMT2AL3MBTL1MEN1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1214287-A1 | AMIDES AS INHIBITORS FOR PYRUVATE DEHYDROGENASE | AstraZeneca AB (SE) | 2002-06-19 | — | — | EP | disclosed |
| WO-2001017942-A1 | AMIDES AS INHIBITORS FOR PYRUVATE DEHYDROGENASE | ASTRAZENECA AB (SE) | 2001-03-15 | — | — | WO | disclosed |