SCHEMBL7549822

SCHEMBL7549822

CN1CC[C@@H]1COCc1cccnc1

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRM2 P08172 3/20 0.66
CHRM1 P11229 3/20 0.66
CHRM3 P20309 3/20 0.66
CHRNB2 P17787 3/20 0.54
CHRNA4 P43681 2/20 0.54
CHRNB1 P11230 2/20 0.54
CHRNB4 P30926 2/20 0.54
CHRNA3 P32297 2/20 0.54
CHRNB3 Q05901 2/20 0.54
CHRNA1 P02708 1/20 0.54
CHRNA7 P36544 1/20 0.54
DAPK3 O43293 1/20 0.48
ROCK2 O75116 1/20 0.48
PRKCG P05129 1/20 0.48
PIM1 P11309 1/20 0.48
RPS6KB1 P23443 1/20 0.48
AKT1 P31749 1/20 0.48
LIMK1 P53667 1/20 0.48
CDK5 Q00535 1/20 0.48
PRKCD Q05655 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7551931 1.00 CHRM2 (0.66) CHRM2CHRM1CHRM3CHRNB2CHRNA4
SCHEMBL7552163 1.00 CHRM2 (0.66) CHRM2CHRM1CHRM3CHRNB2CHRNA4
SCHEMBL7544763 0.92 CHRNB2 (0.66) CHRM2CHRM1CHRM3CHRNB2CHRNA4
SCHEMBL7546116 0.80 CHRNB2 (0.57) CHRM2CHRM1CHRM3CHRNB2CHRNA4
SCHEMBL7546127 0.80 CHRNB2 (0.57) CHRM2CHRM1CHRM3CHRNB2CHRNA4
SCHEMBL30820824 0.77 CHRNA3 (0.86) CHRNB2CHRNA4CHRNB1CHRNB4CHRNA3
SCHEMBL7368701 0.77 CHRNA3 (0.86) CHRNB2CHRNA4CHRNB1CHRNB4CHRNA3
SCHEMBL905202 0.77 CHRNA3 (0.86) CHRNB2CHRNA4CHRNB1CHRNB4CHRNA3
SCHEMBL13424978 0.77 CHRNA3 (0.86) CHRNB2CHRNA4CHRNB1CHRNB4CHRNA3
Hydrochloric Acid SCHEMBL7839188 0.76 CHRNB2 (0.84) CHRNB2CHRNA4CHRNB1CHRNB4CHRNA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1212301-A1 ARYLALKYLOXYALKYLAMINES AND ARYLALKYLTHIOALKYLAMINES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS INHIBITORS OF NICOTINIC CHOLINERGIC RECEPTORS Targacept, Inc. (US) 2002-06-12 EP disclosed
WO-2001016107-A1 ARYLALKYLOXYALKYLAMINES AND ARYLALKYLTHIOALKYLAMINES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS INHIBITORS OF NICOTINIC CHOLINERGIC RECEPTORS TARGACEPT, INC. (US) 2001-03-08 WO disclosed